Overview
| Uniprot ID | Q96ES7 |
|---|
| Protein Name | SAGA-associated factor 29 |
|---|
| Gene Name | SGF29 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 99 |
EERRIAAKIAGLYND |
Function
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity)
Protein Sequence
10
MALVSADSRI
20
AELLTELHQL
30
IKQTQEERSR
40
SEHNLVNIQK
50
THERMQTENK
60
ISPYYRTKLR
70
GLYTTAKADA
80
EAECNILRKA
90
LDKIAEIKSL
100
LEERRIAAKI
110
AGLYNDSEPP
120
RKTMRRGVLM
130
TLLQQSAMTL
140
PLWIGKPGDK
150
PPPLCGAIPA
160
SGDYVARPGD
170
KVAARVKAVD
180
GDEQWILAEV
190
VSYSHATNKY
200
EVDDIDEEGK
210
ERHTLSRRRV
220
IPLPQWKANP
230
ETDPEALFQK
240
EQLVLALYPQ
250
TTCFYRALIH
260
APPQRPQDDY
270
SVLFEDTSYA
280
DGYSPPLNVA
290
QRYVVACKEP
KKK
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0140034 |
methylation-dependent protein binding |
| Cellular Component |
GO:0140672 |
ATAC complex |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000124 |
SAGA complex |
| Cellular Component |
GO:0070461 |
SAGA-type complex |
| Molecular Function |
GO:0140003 |
histone H3K36me3 reader activity |
| Molecular Function |
GO:0140002 |
histone H3K4me3 reader activity |
| Biological Process |
GO:0071169 |
establishment of protein localization to chromatin |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0051302 |
regulation of cell division |
| Biological Process |
GO:0006282 |
regulation of DNA repair |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0045995 |
regulation of embryonic development |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0090043 |
regulation of tubulin deacetylation |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0045815 |
transcription initiation-coupled chromatin remodeling |
Reference
PMID: N/A