Search Results
Overview
| Uniprot ID | Q96EY1 |
|---|---|
| Protein Name | DnaJ homolog subfamily A member 3, mitochondrial |
| Gene Name | DNAJA3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | ASQKEIKKAYYQLAK |
| 118 | KAYYQLAKKYHPDTN |
Function
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway
Protein Sequence
10
MAARCSTRWL
20
LVVVGTPRLP
30
AISGRGARPP
40
REGVVGAWLS
50
RKLSVPAFAS
60
SLTSCGPRAL
70
LTLRPGVSLT
80
GTKHNPFICT
90
ASFHTSAPLA
100
KEDYYQILGV
110
PRNASQKEIK
120
KAYYQLAKKY
130
HPDTNKDDPK
140
AKEKFSQLAE
150
AYEVLSDEVK
160
RKQYDAYGSA
170
GFDPGASGSQ
180
HSYWKGGPTV
190
DPEELFRKIF
200
GEFSSSSFGD
210
FQTVFDQPQE
220
YFMELTFNQA
230
AKGVNKEFTV
240
NIMDTCERCN
250
GKGNEPGTKV
260
QHCHYCGGSG
270
METINTGPFV
280
MRSTCRRCGG
290
RGSIIISPCV
300
VCRGAGQAKQ
310
KKRVMIPVPA
320
GVEDGQTVRM
330
PVGKREIFIT
340
FRVQKSPVFR
350
RDGADIHSDL
360
FISIAQALLG
370
GTARAQGLYE
380
TINVTIPPGT
390
QTDQKIRMGG
400
KGIPRINSYG
410
YGDHYIHIKI
420
RVPKRLTSRQ
430
QSLILSYAED
440
ETDVEGTVNG
450
VTLTSSGGST
460
MDSSAGSKAR
470
REAGEDEEGF
480
LSKLKKMFTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0030695 | GTPase regulator activity |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0106137 | IkappaB kinase complex binding |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0005133 | type II interferon receptor binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060336 | negative regulation of type II interferon-mediated signaling pathway |
| Biological Process | GO:0007528 | neuromuscular junction development |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0002682 | regulation of immune system process |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0034341 | response to type II interferon |
| Biological Process | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.