Search Results

Overview

Uniprot ID	Q96EY8
Protein Name	Corrinoid adenosyltransferase MMAB
Gene Name	MMAB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
141	SAREAHLKYTTFKAG
230	LARYAAMKEGNQEKI
65	IYTKTGDKGFSSTFT

Function

Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191). Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable)

Protein Sequence

10 MAVCGLGSRL 20 GLGSRLGLRG 30 CFGAARLLYP 40 RFQSRGPQGV 50 EDGDRPQPSS 60 KTPRIPKIYT 70 KTGDKGFSST 80 FTGERRPKDD 90 QVFEAVGTTD 100 ELSSAIGFAL 110 ELVTEKGHTF 120 AEELQKIQCT 130 LQDVGSALAT 140 PCSSAREAHL 150 KYTTFKAGPI 160 LELEQWIDKY 170 TSQLPPLTAF 180 ILPSGGKISS 190 ALHFCRAVCR 200 RAERRVVPLV 210 QMGETDANVA 220 KFLNRLSDYL 230 FTLARYAAMK 240 EGNQEKIYMK 250 NDPSAESEGL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0031419	cobalamin binding
Molecular Function	GO:0008817	corrinoid adenosyltransferase activity
Molecular Function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process	GO:0009235	cobalamin metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.