Search Results

Overview

Uniprot ID	Q96EZ8
Protein Name	Microspherule protein 1
Gene Name	MCRS1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
123	TKRVKKSKQPLQVTK
55	SSRFIKRKKFDDELV
56	SRFIKRKKFDDELVE
74	AKSSTRAKGASGVEP

Function

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491)

Protein Sequence

10 MDKDSQGLLD 20 SSLMASGTAS 30 RSEDEESLAG 40 QKRASSQALG 50 TIPKRRSSSR 60 FIKRKKFDDE 70 LVESSLAKSS 80 TRAKGASGVE 90 PGRCSGSEPS 100 SSEKKKVSKA 110 PSTPVPPSPA 120 PAPGLTKRVK 130 KSKQPLQVTK 140 DLGRWKPADD 150 LLLINAVLQT 160 NDLTSVHLGV 170 KFSCRFTLRE 180 VQERWYALLY 190 DPVISKLACQ 200 AMRQLHPEAI 210 AAIQSKALFS 220 KAEEQLLSKV 230 GSTSQPTLET 240 FQDLLHRHPD 250 AFYLARTAKA 260 LQAHWQLMKQ 270 YYLLEDQTVQ 280 PLPKGDQVLN 290 FSDAEDLIDD 300 SKLKDMRDEV 310 LEHELMVADR 320 RQKREIRQLE 330 QELHKWQVLV 340 DSITGMSSPD 350 FDNQTLAVLR 360 GRMVRYLMRS 370 REITLGRATK 380 DNQIDVDLSL 390 EGPAWKISRK 400 QGVIKLKNNG 410 DFFIANEGRR 420 PIYIDGRPVL 430 CGSKWRLSNN 440 SVVEIASLRF 450 VFLINQDLIA 460 LIRAEAAKIT PQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0034451	centriolar satellite
Biological Process	GO:0045739	positive regulation of DNA repair
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1904751	positive regulation of protein localization to nucleolus
Biological Process	GO:1904507	positive regulation of telomere maintenance in response to DNA damage
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0036211	protein modification process
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0033044	regulation of chromosome organization
Biological Process	GO:0006275	regulation of DNA replication
Biological Process	GO:0060382	regulation of DNA strand elongation
Biological Process	GO:0045995	regulation of embryonic development
Biological Process	GO:0000723	telomere maintenance
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0000123	histone acetyltransferase complex
Cellular Component	GO:0031011	Ino80 complex
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0071339	MLL1 complex
Cellular Component	GO:0044545	NSL complex
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0043204	perikaryon
Cellular Component	GO:0000922	spindle pole
Molecular Function	GO:0002151	G-quadruplex RNA binding
Molecular Function	GO:0034046	poly(G) binding
Molecular Function	GO:0008266	poly(U) RNA binding
Molecular Function	GO:0010521	telomerase inhibitor activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006310	DNA recombination
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.