Search Results
Overview
| Uniprot ID | Q96F10 |
|---|---|
| Protein Name | Thialysine N-epsilon-acetyltransferase |
| Gene Name | SAT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | IGSKIIKKVAEVALD |
| 35 | EKLSDQVKISEEALR |
Function
Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur (PubMed:15283699). May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine (PubMed:12803540). However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo (PubMed:15283699)
Protein Sequence
10
MASVRIREAK
20
EGDCGDILRL
30
IRELAEFEKL
40
SDQVKISEEA
50
LRADGFGDNP
60
FYHCLVAEIL
70
PAPGKLLGPC
80
VVGYGIYYFI
90
YSTWKGRTIY
100
LEDIYVMPEY
110
RGQGIGSKII
120
KKVAEVALDK
130
GCSQFRLAVL
140
DWNQRAMDLY
150
KALGAQDLTE
160
AEGWHFFCFQ
170
GEATRKLAGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0046204 | nor-spermidine metabolic process |
| Biological Process | GO:0032920 | putrescine acetylation |
| Biological Process | GO:0032918 | spermidine acetylation |
| Biological Process | GO:0032919 | spermine acetylation |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004145 | diamine N-acetyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008080 | N-acetyltransferase activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.