Overview
| Uniprot ID | Q96F15 |
|---|
| Protein Name | GTPase IMAP family member 5 |
|---|
| Gene Name | GIMAP5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 255 |
KVEWQVEKHKQELRE |
Function
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity)
Protein Sequence
10
MGGFQRGKYG
20
TMAEGRSEDN
30
LSATPPALRI
40
ILVGKTGCGK
50
SATGNSILGQ
60
PVFESKLRAQ
70
SVTRTCQVKT
80
GTWNGRKVLV
90
VDTPSIFESQ
100
ADTQELYKNI
110
GDCYLLSAPG
120
PHVLLLVIQL
130
GRFTAQDTVA
140
IRKVKEVFGT
150
GAMRHVVILF
160
THKEDLGGQA
170
LDDYVANTDN
180
CSLKDLVREC
190
ERRYCAFNNW
200
GSVEEQRQQQ
210
AELLAVIERL
220
GREREGSFHS
230
NDLFLDAQLL
240
QRTGAGACQE
250
DYRQYQAKVE
260
WQVEKHKQEL
270
RENESNWAYK
280
ALLRVKHLML
290
LHYEIFVFLL
300
LCSILFFIIF
LFIFHYI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0032585 |
multivesicular body membrane |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.