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Overview

Uniprot IDQ96F24
Protein NameNuclear receptor-binding factor 2
Gene NameNRBF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
159 AEPCIGSKAPKDDKT
252 KFAANTGKAKDIPIP

Function

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)

Protein Sequence

10 MEVMEGPLNL 20 AHQQSRRADR 30 LLAAGKYEEA 40 ISCHKKAAAY 50 LSEAMKLTQS 60 EQAHLSLELQ 70 RDSHMKQLLL 80 IQERWKRAQR 90 EERLKAQQNT 100 DKDAAAHLQT 110 SHKPSAEDAE 120 GQSPLSQKYS 130 PSTEKCLPEI 140 QGIFDRDPDT 150 LLYLLQQKSE 160 PAEPCIGSKA 170 PKDDKTIIEE 180 QATKIADLKR 190 HVEFLVAENE 200 RLRKENKQLK 210 AEKARLLKGP 220 IEKELDVDAD 230 FVETSELWSL 240 PPHAETATAS 250 STWQKFAANT 260 GKAKDIPIPN 270 LPPLDFPSPE 280 LPLMELSEDI LKGFMNN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0035032 phosphatidylinositol 3-kinase complex, class III
Biological Process GO:0006914 autophagy
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0034976 response to endoplasmic reticulum stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.