Search Results

Overview

Uniprot IDQ96F81
Protein NameProtein dispatched homolog 1
Gene NameDISP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
671 LNIFTCFKKPQQQIY

Function

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404)

Protein Sequence

10 MAMSNGNNDF 20 VVLSNSSIAT 30 SAANPSPLTP 40 CDGDHAAQQL 50 TPKEATRTKV 60 SPNGCLQLNG 70 TVKSSFLPLD 80 NQRMPQMLPQ 90 CCHPCPYHHP 100 LTSHSSHQEC 110 HPEAGPAAPS 120 ALASCCMQPH 130 SEYSASLCPN 140 HSPVYQTTCC 150 LQPSPSFCLH 160 HPWPDHFQHQ 170 PVQQHIANIR 180 PSRPFKLPKS 190 YAALIADWPV 200 VVLGMCTMFI 210 VVCALVGVLV 220 PELPDFSDPL 230 LGFEPRGTAI 240 GQRLVTWNNM 250 VKNTGYKATL 260 ANYPFKYADE 270 QAKSHRDDRW 280 SDDHYEREKR 290 EVDWNFHKDS 300 FFCDVPSDRY 310 SRVVFTSSGG 320 ETLWNLPAIK 330 SMCNVDNSRI 340 RSHPQFGDLC 350 QRTTAASCCP 360 SWTLGNYIAI 370 LNNRSSCQKI 380 VERDVSHTLK 390 LLRTCAKHYQ 400 NGTLGPDCWD 410 MAARRKDQLK 420 CTNVPRKCTK 430 YNAVYQILHY 440 LVDKDFMTPK 450 TADYATPALK 460 YSMLFSPTEK 470 GESMMNIYLD 480 NFENWNSSDG 490 VTTITGIEFG 500 IKHSLFQDYL 510 LMDTVYPAIA 520 IVIVLLVMCV 530 YTKSMFITLM 540 TMFAIISSLI 550 VSYFLYRVVF 560 HFEFFPFMNL 570 TALIILVGIG 580 ADDAFVLCDV 590 WNYTKFDKPH 600 AETSETVSIT 610 LQHAALSMFV 620 TSFTTAAAFY 630 ANYVSNITAI 640 RCFGVYAGTA 650 ILVNYVLMVT 660 WLPAVVVLHE 670 RYLLNIFTCF 680 KKPQQQIYDN 690 KSCWTVACQK 700 CHKVLFAISE 710 ASRIFFEKVL 720 PCIVIKFRYL 730 WLFWFLALTV 740 GGAYIVCINP 750 KMKLPSLELS 760 EFQVFRSSHP 770 FERYDAEYKK 780 LFMFERVHHG 790 EELHMPITVI 800 WGVSPEDNGN 810 PLNPKSKGKL 820 TLDSSFNIAS 830 PASQAWILHF 840 CQKLRNQTFF 850 YQTDEQDFTS 860 CFIETFKQWM 870 ENQDCDEPAL 880 YPCCSHWSFP 890 YKQEIFELCI 900 KRAIMELERS 910 TGYHLDSKTP 920 GPRFDINDTI 930 RAVVLEFQST 940 YLFTLAYEKM 950 HQFYKEVDSW 960 ISSELSSAPE 970 GLSNGWFVSN 980 LEFYDLQDSL 990 SDGTLIAMGL 1000 SVAVAFSVML 1010 LTTWNIIISL 1020 YAIISIAGTI 1030 FVTVGSLVLL 1040 GWELNVLESV 1050 TISVAVGLSV 1060 DFAVHYGVAY 1070 RLAPDPDREG 1080 KVIFSLSRVG 1090 SAMAMAALTT 1100 FVAGAMMMPS 1110 TVLAYTQLGT 1120 FMMLIMCISW 1130 AFATFFFQCM 1140 CRCLGPQGTC 1150 GQIPLPKKLQ 1160 CSAFSHALST 1170 SPSDKGQSKT 1180 HTINAYHLDP 1190 RGPKSELEHE 1200 FYELEPLASH 1210 SCTAPEKTTY 1220 EETHICSEFF 1230 NSQAKNLGMP 1240 VHAAYNSELS 1250 KSTESDAGSA 1260 LLQPPLEQHT 1270 VCHFFSLNQR 1280 CSCPDAYKHL 1290 NYGPHSCQQM 1300 GDCLCHQCSP 1310 TTSSFVQIQN 1320 GVAPLKATHQ 1330 AVEGFVHPIT 1340 HIHHCPCLQG 1350 RVKPAGMQNS 1360 LPRNFFLHPV 1370 QHIQAQEKIG 1380 KTNVHSLQRS 1390 IEEHLPKMAE 1400 PSSFVCRSTG 1410 SLLKTCCDPE 1420 NKQRELCKNR 1430 DVSNLESSGG 1440 TENKAGGKVE 1450 LSLSQTDASV 1460 NSEHFNQNEP 1470 KVLFNHLMGE 1480 AGCRSCPNNS 1490 QSCGRIVRVK 1500 CNSVDCQMPN 1510 MEANVPAVLT 1520 HSELSGESLL IKTL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0016020 membrane
Molecular Function GO:0140104 molecular carrier activity
Biological Process GO:0060539 diaphragm development
Biological Process GO:0015833 peptide transport
Biological Process GO:0050708 regulation of protein secretion
Biological Process GO:0007224 smoothened signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.