Search Results
Overview
| Uniprot ID | Q96F81 |
|---|---|
| Protein Name | Protein dispatched homolog 1 |
| Gene Name | DISP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 671 | LNIFTCFKKPQQQIY |
Function
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404)
Protein Sequence
10
MAMSNGNNDF
20
VVLSNSSIAT
30
SAANPSPLTP
40
CDGDHAAQQL
50
TPKEATRTKV
60
SPNGCLQLNG
70
TVKSSFLPLD
80
NQRMPQMLPQ
90
CCHPCPYHHP
100
LTSHSSHQEC
110
HPEAGPAAPS
120
ALASCCMQPH
130
SEYSASLCPN
140
HSPVYQTTCC
150
LQPSPSFCLH
160
HPWPDHFQHQ
170
PVQQHIANIR
180
PSRPFKLPKS
190
YAALIADWPV
200
VVLGMCTMFI
210
VVCALVGVLV
220
PELPDFSDPL
230
LGFEPRGTAI
240
GQRLVTWNNM
250
VKNTGYKATL
260
ANYPFKYADE
270
QAKSHRDDRW
280
SDDHYEREKR
290
EVDWNFHKDS
300
FFCDVPSDRY
310
SRVVFTSSGG
320
ETLWNLPAIK
330
SMCNVDNSRI
340
RSHPQFGDLC
350
QRTTAASCCP
360
SWTLGNYIAI
370
LNNRSSCQKI
380
VERDVSHTLK
390
LLRTCAKHYQ
400
NGTLGPDCWD
410
MAARRKDQLK
420
CTNVPRKCTK
430
YNAVYQILHY
440
LVDKDFMTPK
450
TADYATPALK
460
YSMLFSPTEK
470
GESMMNIYLD
480
NFENWNSSDG
490
VTTITGIEFG
500
IKHSLFQDYL
510
LMDTVYPAIA
520
IVIVLLVMCV
530
YTKSMFITLM
540
TMFAIISSLI
550
VSYFLYRVVF
560
HFEFFPFMNL
570
TALIILVGIG
580
ADDAFVLCDV
590
WNYTKFDKPH
600
AETSETVSIT
610
LQHAALSMFV
620
TSFTTAAAFY
630
ANYVSNITAI
640
RCFGVYAGTA
650
ILVNYVLMVT
660
WLPAVVVLHE
670
RYLLNIFTCF
680
KKPQQQIYDN
690
KSCWTVACQK
700
CHKVLFAISE
710
ASRIFFEKVL
720
PCIVIKFRYL
730
WLFWFLALTV
740
GGAYIVCINP
750
KMKLPSLELS
760
EFQVFRSSHP
770
FERYDAEYKK
780
LFMFERVHHG
790
EELHMPITVI
800
WGVSPEDNGN
810
PLNPKSKGKL
820
TLDSSFNIAS
830
PASQAWILHF
840
CQKLRNQTFF
850
YQTDEQDFTS
860
CFIETFKQWM
870
ENQDCDEPAL
880
YPCCSHWSFP
890
YKQEIFELCI
900
KRAIMELERS
910
TGYHLDSKTP
920
GPRFDINDTI
930
RAVVLEFQST
940
YLFTLAYEKM
950
HQFYKEVDSW
960
ISSELSSAPE
970
GLSNGWFVSN
980
LEFYDLQDSL
990
SDGTLIAMGL
1000
SVAVAFSVML
1010
LTTWNIIISL
1020
YAIISIAGTI
1030
FVTVGSLVLL
1040
GWELNVLESV
1050
TISVAVGLSV
1060
DFAVHYGVAY
1070
RLAPDPDREG
1080
KVIFSLSRVG
1090
SAMAMAALTT
1100
FVAGAMMMPS
1110
TVLAYTQLGT
1120
FMMLIMCISW
1130
AFATFFFQCM
1140
CRCLGPQGTC
1150
GQIPLPKKLQ
1160
CSAFSHALST
1170
SPSDKGQSKT
1180
HTINAYHLDP
1190
RGPKSELEHE
1200
FYELEPLASH
1210
SCTAPEKTTY
1220
EETHICSEFF
1230
NSQAKNLGMP
1240
VHAAYNSELS
1250
KSTESDAGSA
1260
LLQPPLEQHT
1270
VCHFFSLNQR
1280
CSCPDAYKHL
1290
NYGPHSCQQM
1300
GDCLCHQCSP
1310
TTSSFVQIQN
1320
GVAPLKATHQ
1330
AVEGFVHPIT
1340
HIHHCPCLQG
1350
RVKPAGMQNS
1360
LPRNFFLHPV
1370
QHIQAQEKIG
1380
KTNVHSLQRS
1390
IEEHLPKMAE
1400
PSSFVCRSTG
1410
SLLKTCCDPE
1420
NKQRELCKNR
1430
DVSNLESSGG
1440
TENKAGGKVE
1450
LSLSQTDASV
1460
NSEHFNQNEP
1470
KVLFNHLMGE
1480
AGCRSCPNNS
1490
QSCGRIVRVK
1500
CNSVDCQMPN
1510
MEANVPAVLT
1520
HSELSGESLL
IKTL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0140104 | molecular carrier activity |
| Biological Process | GO:0060539 | diaphragm development |
| Biological Process | GO:0015833 | peptide transport |
| Biological Process | GO:0050708 | regulation of protein secretion |
| Biological Process | GO:0007224 | smoothened signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.