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Overview

Uniprot IDQ96F85
Protein NameCB1 cannabinoid receptor-interacting protein 1
Gene NameCNRIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
98 TEGVTPTKSGERQPI

Function

Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels

Protein Sequence

10 MGDLPGLVRL 20 SIALRIQPND 30 GPVFYKVDGQ 40 RFGQNRTIKL 50 LTGSSYKVEV 60 KIKPSTLQVE 70 NISIGGVLVP 80 LELKSKEPDG 90 DRVVYTGTYD 100 TEGVTPTKSG 110 ERQPIQITMP 120 FTDIGTFETV 130 WQVKFYNYHK 140 RDHCQWGSPF 150 SVIEYECKPN 160 ETRSLMWVNK ESFL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Molecular Function GO:0031718 type 1 cannabinoid receptor binding
Biological Process GO:2000272 negative regulation of signaling receptor activity
Biological Process GO:0010469 regulation of signaling receptor activity
Biological Process GO:0150036 regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.