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Overview

Uniprot ID	Q96FJ0
Protein Name	AMSH-like protease
Gene Name	STAMBPL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
12	FTVNSLKKLAAMPDH
144	LQSKNKYKAEILKKL

Function

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443)

Protein Sequence

10 MDQPFTVNSL 20 KKLAAMPDHT 30 DVSLSPEERV 40 RALSKLGCNI 50 TISEDITPRR 60 YFRSGVEMER 70 MASVYLEEGN 80 LENAFVLYNK 90 FITLFVEKLP 100 NHRDYQQCAV 110 PEKQDIMKKL 120 KEIAFPRTDE 130 LKNDLLKKYN 140 VEYQEYLQSK 150 NKYKAEILKK 160 LEHQRLIEAE 170 RKRIAQMRQQ 180 QLESEQFLFF 190 EDQLKKQELA 200 RGQMRSQQTS 210 GLSEQIDGSA 220 LSCFSTHQNN 230 SLLNVFADQP 240 NKSDATNYAS 250 HSPPVNRALT 260 PAATLSAVQN 270 LVVEGLRCVV 280 LPEDLCHKFL 290 QLAESNTVRG 300 IETCGILCGK 310 LTHNEFTITH 320 VIVPKQSAGP 330 DYCDMENVEE 340 LFNVQDQHDL 350 LTLGWIHTHP 360 TQTAFLSSVD 370 LHTHCSYQLM 380 LPEAIAIVCS 390 PKHKDTGIFR 400 LTNAGMLEVS 410 ACKKKGFHPH 420 TKEPRLFSIC 430 KHVLVKDIKI IVLDLR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0016020	membrane
Molecular Function	GO:0061578	K63-linked deubiquitinase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity
Biological Process	GO:0071233	cellular response to L-leucine
Biological Process	GO:1904263	positive regulation of TORC1 signaling
Biological Process	GO:0016579	protein deubiquitination
Biological Process	GO:0070536	protein K63-linked deubiquitination
Biological Process	GO:0006508	proteolysis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.