Search Results
Overview
| Uniprot ID | Q96FN5 |
|---|---|
| Protein Name | Kinesin-like protein KIF12 |
| Gene Name | KIF12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | CTVFTFGQTGSGKTY |
Function
Involved in the negative regulation of fatty acid biosynthesis, probably acting as an adapter that allows ubiquitination of acetyl-CoA carboxylase 1 (ACACA) by E3 ubiquitin-protein ligase COP1, and promotes ACACA degradation (PubMed:39920308). The adapter function requires the C-terminal proline-rich domain and may be apart from the kinesin motor activity (Probable)
Protein Sequence
10
MEERGSPDGD
20
LARSLEQGPE
30
GPETPIQVVL
40
RVRPMSAAEL
50
RRGQQSVLHC
60
SGTRTLQVSP
70
PGGGPEVAFR
80
FGAVLDAART
90
QEDVFRACGV
100
RRLGELALRG
110
FSCTVFTFGQ
120
TGSGKTYTLT
130
GPPPQGEGVP
140
VPPSLAGIMQ
150
RTFAWLLDRV
160
QHLGAPVTLR
170
ASYLEIYNEQ
180
VRDLLSLGSP
190
RPLPVRWNKT
200
RGFYVEQLRV
210
VEFGSLEALM
220
ELLQTGLSRR
230
RNSAHTLNQA
240
SSRSHALLTL
250
YISRQTAQQM
260
PSVDPGEPPV
270
GGKLCFVDLA
280
GSEKVAATGS
290
RGELMLEANS
300
INRSLLALGH
310
CISLLLDPQR
320
KQSHIPFRDS
330
KLTKLLADSL
340
GGRGVTLMVA
350
CVSPSAQCLP
360
ETLSTLRYAS
370
RAQRVTTRPQ
380
APKSPVAKQP
390
QRLETEMLQL
400
QEENRRLQFQ
410
LDQMDCKASG
420
LSGARVAWAQ
430
RNLYGMLQEF
440
MLENERLRKE
450
KSQLQNSRDL
460
AQNEQRILAQ
470
QVHALERRLL
480
SACYHHQQGP
490
GLTPPCPCLM
500
APAPPCHALP
510
PLYSCPCCHI
520
CPLCRVPLAH
530
WACLPGEHHL
540
PQVLDPEASG
550
GRPPSARPPP
560
WAPPCSPGSA
570
KCPRERSHSD
580
WTQTRVLAEM
590
LTEEEVVPSA
600
PPLPVRPPKT
610
SPGLRGGAGV
620
PNLAQRLEAL
630
RDQIGSSLRR
640
GRSQPPCSEG
650
ARSPGQVLPP
H
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0005874 | microtubule |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.