Search Results

Overview

Uniprot IDQ96G03
Protein NamePhosphopentomutase
Gene NamePGM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
249 VNRETKVKFVHTSVH
292 DPEFPTVKYPNPEEG
36 SLTLEAVKRLIAEGN
491 CHDQETIKKLFENLR
492 HDQETIKKLFENLRN
503 NLRNYDGKNNYPKAC
532 YDDSQPDKKAVLPTS
567 SGTEPKIKYYAELCA

Function

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed:17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed:17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:17804405). In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed:17804405, PubMed:18927083)

Protein Sequence

10 MAAPEGSGLG 20 EDARLDQETA 30 QWLRWDKNSL 40 TLEAVKRLIA 50 EGNKEELRKC 60 FGARMEFGTA 70 GLRAAMGPGI 80 SRMNDLTIIQ 90 TTQGFCRYLE 100 KQFSDLKQKG 110 IVISFDARAH 120 PSSGGSSRRF 130 ARLAATTFIS 140 QGIPVYLFSD 150 ITPTPFVPFT 160 VSHLKLCAGI 170 MITASHNPKQ 180 DNGYKVYWDN 190 GAQIISPHDK 200 GISQAIEENL 210 EPWPQAWDDS 220 LIDSSPLLHN 230 PSASINNDYF 240 EDLKKYCFHR 250 SVNRETKVKF 260 VHTSVHGVGH 270 SFVQSAFKAF 280 DLVPPEAVPE 290 QKDPDPEFPT 300 VKYPNPEEGK 310 GVLTLSFALA 320 DKTKARIVLA 330 NDPDADRLAV 340 AEKQDSGEWR 350 VFSGNELGAL 360 LGWWLFTSWK 370 EKNQDRSALK 380 DTYMLSSTVS 390 SKILRAIALK 400 EGFHFEETLT 410 GFKWMGNRAK 420 QLIDQGKTVL 430 FAFEEAIGYM 440 CCPFVLDKDG 450 VSAAVISAEL 460 ASFLATKNLS 470 LSQQLKAIYV 480 EYGYHITKAS 490 YFICHDQETI 500 KKLFENLRNY 510 DGKNNYPKAC 520 GKFEISAIRD 530 LTTGYDDSQP 540 DKKAVLPTSK 550 SSQMITFTFA 560 NGGVATMRTS 570 GTEPKIKYYA 580 ELCAPPGNSD 590 PEQLKKELNE 600 LVSAIEEHFF 610 QPQKYNLQPK AD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0004614 phosphoglucomutase activity
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0008973 phosphopentomutase activity
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0005978 glycogen biosynthetic process
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0006166 purine ribonucleoside salvage

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.