Search Results
Overview
| Uniprot ID | Q96G25 |
|---|---|
| Protein Name | Mediator of RNA polymerase II transcription subunit 8 |
| Gene Name | MED8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 259 | SGIKTNIKSASMHPY |
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins
Protein Sequence
10
MQREEKQLEA
20
SLDALLSQVA
30
DLKNSLGSFI
40
CKLENEYGRL
50
TWPSVLDSFA
60
LLSGQLNTLN
70
KVLKHEKTPL
80
FRNQVIIPLV
90
LSPDRDEDLM
100
RQTEGRVPVF
110
SHEVVPDHLR
120
TKPDPEVEEQ
130
EKQLTTDAAR
140
IGADAAQKQI
150
QSLNKMCSNL
160
LEKISKEERE
170
SESGGLRPNK
180
QTFNPTDTNA
190
LVAAVAFGKG
200
LSNWRPSGSS
210
GPGQAGQPGA
220
GTILAGTSGL
230
QQVQMAGAPS
240
QQQPMLSGVQ
250
MAQAGQPGKM
260
PSGIKTNIKS
ASMHPYQR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070847 | core mediator complex |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
| Cellular Component | GO:0016592 | mediator complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
Reference
PMID: N/A