Search Results
Overview
| Uniprot ID | Q96G46 |
|---|---|
| Protein Name | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like |
| Gene Name | DUS3L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | GEQLQTQKRARGQNK |
| 114 | NKGRPHVKPTNYDKN |
Function
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860)
Protein Sequence
10
MAEGTAEAPL
20
ENGGGGDSGA
30
GALERGVAPI
40
KRQYLTTKEQ
50
FHQFLEAKGQ
60
EKTCRETEVG
70
DPAGNELAEP
80
EAKRIRLEDG
90
QTADGQTEEA
100
AEPGEQLQTQ
110
KRARGQNKGR
120
PHVKPTNYDK
130
NRLCPSLIQE
140
SAAKCFFGDR
150
CRFLHDVGRY
160
LETKPADLGP
170
RCVLFETFGR
180
CPYGVTCRFA
190
GAHLRPEGQN
200
LVQEELAARG
210
TQPPSIRNGL
220
DKALQQQLRK
230
REVRFERAEQ
240
ALRRFSQGPT
250
PAAAVPEGTA
260
AEGAPRQENC
270
GAQQVPAGPG
280
TSTPPSSPVR
290
TCGPLTDEDV
300
VRLRPCEKKR
310
LDIRGKLYLA
320
PLTTCGNLPF
330
RRICKRFGAD
340
VTCGEMAVCT
350
NLLQGQMSEW
360
ALLKRHQCED
370
IFGVQLEGAF
380
PDTMTKCAEL
390
LSRTVEVDFV
400
DINVGCPIDL
410
VYKKGGGCAL
420
MNRSTKFQQI
430
VRGMNQVLDV
440
PLTVKIRTGV
450
QERVNLAHRL
460
LPELRDWGVA
470
LVTLHGRSRE
480
QRYTKLADWQ
490
YIEECVQAAS
500
PMPLFGNGDI
510
LSFEDANRAM
520
QTGVTGIMIA
530
RGALLKPWLF
540
TEIKEQRHWD
550
ISSSERLDIL
560
RDFTNYGLEH
570
WGSDTQGVEK
580
TRRFLLEWLS
590
FLCRYVPVGL
600
LERLPQRINE
610
RPPYYLGRDY
620
LETLMASQKA
630
ADWIRISEML
640
LGPVPPSFAF
650
LPKHKANAYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0106414 | mRNA dihydrouridine synthase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0017150 | tRNA dihydrouridine synthase activity |
| Molecular Function | GO:0102265 | tRNA-dihydrouridine47 synthase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0002943 | tRNA dihydrouridine synthesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.