Overview
| Uniprot ID | Q96G74 |
|---|
| Protein Name | OTU domain-containing protein 5 |
|---|
| Gene Name | OTUD5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 429 |
RGPSQPRKASATCSS |
Function
Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214)
Protein Sequence
10
MTILPKKKPP
20
PPDADPANEP
30
PPPGPMPPAP
40
RRGGGVGVGG
50
GGTGVGGGDR
60
DRDSGVVGAR
70
PRASPPPQGP
80
LPGPPGALHR
90
WALAVPPGAV
100
AGPRPQQASP
110
PPCGGPGGPG
120
GGPGDALGAA
130
AAGVGAAGVV
140
VGVGGAVGVG
150
GCCSGPGHSK
160
RRRQAPGVGA
170
VGGGSPEREE
180
VGAGYNSEDE
190
YEAAAARIEA
200
MDPATVEQQE
210
HWFEKALRDK
220
KGFIIKQMKE
230
DGACLFRAVA
240
DQVYGDQDMH
250
EVVRKHCMDY
260
LMKNADYFSN
270
YVTEDFTTYI
280
NRKRKNNCHG
290
NHIEMQAMAE
300
MYNRPVEVYQ
310
YSTGTSAVEP
320
INTFHGIHQN
330
EDEPIRVSYH
340
RNIHYNSVVN
350
PNKATIGVGL
360
GLPSFKPGFA
370
EQSLMKNAIK
380
TSEESWIEQQ
390
MLEDKKRATD
400
WEATNEAIEE
410
QVARESYLQW
420
LRDQEKQARQ
430
VRGPSQPRKA
440
SATCSSATAA
450
ASSGLEEWTS
460
RSPRQRSSAS
470
SPEHPELHAE
480
LGMKPPSPGT
490
VLALAKPPSP
500
CAPGTSSQFS
510
AGADRATSPL
520
VSLYPALECR
530
ALIQQMSPSA
540
FGLNDWDDDE
550
ILASVLAVSQ
560
QEYLDSMKKN
570
KVHRDPPPDK
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0004843 |
cysteine-type deubiquitinase activity |
| Molecular Function |
GO:0101005 |
deubiquitinase activity |
| Molecular Function |
GO:1990380 |
K48-linked deubiquitinase activity |
| Molecular Function |
GO:0061578 |
K63-linked deubiquitinase activity |
| Biological Process |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:0032480 |
negative regulation of type I interferon production |
| Biological Process |
GO:0014033 |
neural crest cell differentiation |
| Biological Process |
GO:1904263 |
positive regulation of TORC1 signaling |
| Biological Process |
GO:1904515 |
positive regulation of TORC2 signaling |
| Biological Process |
GO:0016579 |
protein deubiquitination |
| Biological Process |
GO:0071108 |
protein K48-linked deubiquitination |
| Biological Process |
GO:0070536 |
protein K63-linked deubiquitination |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0050776 |
regulation of immune response |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.