Search Results
Overview
| Uniprot ID | Q96GA7 |
|---|---|
| Protein Name | Serine dehydratase-like |
| Gene Name | SDSL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 232 | VAKSLGAKTVAARAL |
Function
Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively (PubMed:16580895, PubMed:18342636). Also exhibits racemase activity towards L-glutamate and D-glutamate (By similarity)
Protein Sequence
10
MDGPVAEHAK
20
QEPFHVVTPL
30
LESWALSQVA
40
GMPVFLKCEN
50
VQPSGSFKIR
60
GIGHFCQEMA
70
KKGCRHLVCS
80
SGGNAGIAAA
90
YAARKLGIPA
100
TIVLPESTSL
110
QVVQRLQGEG
120
AEVQLTGKVW
130
DEANLRAQEL
140
AKRDGWENVP
150
PFDHPLIWKG
160
HASLVQELKA
170
VLRTPPGALV
180
LAVGGGGLLA
190
GVVAGLLEVG
200
WQHVPIIAME
210
THGAHCFNAA
220
ITAGKLVTLP
230
DITSVAKSLG
240
AKTVAARALE
250
CMQVCKIHSE
260
VVEDTEAVSA
270
VQQLLDDERM
280
LVEPACGAAL
290
AAIYSGLLRR
300
LQAEGCLPPS
310
LTSVVVIVCG
320
GNNINSRELQ
ALKTHLGQV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008881 | glutamate racemase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003941 | L-serine ammonia-lyase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0004794 | threonine deaminase activity |
| Biological Process | GO:0006565 | L-serine catabolic process |
| Biological Process | GO:0006567 | L-threonine catabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.