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Overview

Uniprot IDQ96GE6
Protein NameCalmodulin-like protein 4
Gene NameCALML4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
138 LAMLMVDKEKKGYVM

Function

As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli

Protein Sequence

10 MAAEHLLPGP 20 PPSLADFRLE 30 AGGKGTERGS 40 GSSKPTGSSR 50 GPRMAKFLSQ 60 DQINEYKECF 70 SLYDKQQRGK 80 IKATDLMVAM 90 RCLGASPTPG 100 EVQRHLQTHG 110 IDGNGELDFS 120 TFLTIMHMQI 130 KQEDPKKEIL 140 LAMLMVDKEK 150 KGYVMASDLR 160 SKLTSLGEKL 170 THKEVDDLFR 180 EADIEPNGKV 190 KYDEFIHKIT LPGRDY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005902 microvillus
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030234 enzyme regulator activity
Molecular Function GO:0032028 myosin head/neck binding
Biological Process GO:1904970 brush border assembly
Biological Process GO:0000226 microtubule cytoskeleton organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.