Overview
| Uniprot ID | Q96GG9 |
|---|
| Protein Name | DCN1-like protein 1 |
|---|
| Gene Name | DCUN1D1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 57 |
LYIRESVKGSLDRKK |
Function
Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity)
Protein Sequence
10
MNKLKSSQKD
20
KVRQFMIFTQ
30
SSEKTAVSCL
40
SQNDWKLDVA
50
TDNFFQNPEL
60
YIRESVKGSL
70
DRKKLEQLYN
80
RYKDPQDENK
90
IGIDGIQQFC
100
DDLALDPASI
110
SVLIIAWKFR
120
AATQCEFSKQ
130
EFMDGMTELG
140
CDSIEKLKAQ
150
IPKMEQELKE
160
PGRFKDFYQF
170
TFNFAKNPGQ
180
KGLDLEMAIA
190
YWNLVLNGRF
200
KFLDLWNKFL
210
LEHHKRSIPK
220
DTWNLLLDFS
230
TMIADDMSNY
240
DEEGAWPVLI
250
DDFVEFARPQ
IAGTKSTTV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000151 |
ubiquitin ligase complex |
| Molecular Function |
GO:0097602 |
cullin family protein binding |
| Molecular Function |
GO:0031624 |
ubiquitin conjugating enzyme binding |
| Molecular Function |
GO:0032182 |
ubiquitin-like protein binding |
| Biological Process |
GO:2000436 |
positive regulation of protein neddylation |
| Biological Process |
GO:0045116 |
protein neddylation |
| Biological Process |
GO:2000434 |
regulation of protein neddylation |
| Biological Process |
GO:0031396 |
regulation of protein ubiquitination |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.