Search Results
Overview
| Uniprot ID | Q96GK7 |
|---|---|
| Protein Name | Oxaloacetate tautomerase FAHD2A, mitochondrial |
| Gene Name | FAHD2A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EQNVPVPKEPIIFSK |
| 174 | GKKGKHIKATDAMAH |
| 203 | WQMRRNGKQWLLGKT |
| 234 | VADPHNLKICCRVNG |
Function
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (PubMed:38287013). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (PubMed:38287013)
Protein Sequence
10
MLVSGRRRLL
20
TVLLQAQKWP
30
FQPSRDMRLV
40
QFRAPHLVGP
50
HLGLETGNGG
60
GVINLNAFDP
70
TLPKTMTQFL
80
EQGEATLSVA
90
RRALAAQLPV
100
LPRSEVTFLA
110
PVTRPDKVVC
120
VGMNYVDHCK
130
EQNVPVPKEP
140
IIFSKFASSI
150
VGPYDEVVLP
160
PQSQEVDWEV
170
ELAVVIGKKG
180
KHIKATDAMA
190
HVAGFTVAHD
200
VSARDWQMRR
210
NGKQWLLGKT
220
FDTFCPLGPA
230
LVTKDSVADP
240
HNLKICCRVN
250
GEVVQSGNTN
260
QMVFKTEDLI
270
AWVSQFVTFY
280
PGDVILTGTP
290
PGVGVFRKPP
300
VFLKKGDEVQ
310
CEIEELGVII
NKVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050163 | oxaloacetate tautomerase activity |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.