Search Results
Overview
| Uniprot ID | Q96GM8 |
|---|---|
| Protein Name | Target of EGR1 protein 1 |
| Gene Name | TOE1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 368 | AKDGPPKKQVCGDSI |
| 376 | QVCGDSIKPEETEQE |
| 396 | TRNLPHSKQGNKNDL |
Function
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684)
Protein Sequence
10
MAADSDDGAV
20
SAPAASDGGV
30
SKSTTSGEEL
40
VVQVPVVDVQ
50
SNNFKEMWPS
60
LLLAIKTANF
70
VAVDTELSGL
80
GDRKSLLNQC
90
IEERYKAVCH
100
AARTRSILSL
110
GLACFKRQPD
120
KGEHSYLAQV
130
FNLTLLCMEE
140
YVIEPKSVQF
150
LIQHGFNFNQ
160
QYAQGIPYHK
170
GNDKGDESQS
180
QSVRTLFLEL
190
IRARRPLVLH
200
NGLIDLVFLY
210
QNFYAHLPES
220
LGTFTADLCE
230
MFPAGIYDTK
240
YAAEFHARFV
250
ASYLEYAFRK
260
CERENGKQRA
270
AGSPHLTLEF
280
CNYPSSMRDH
290
IDYRCCLPPA
300
THRPHPTSIC
310
DNFSAYGWCP
320
LGPQCPQSHD
330
IDLIIDTDEA
340
AAEDKRRRRR
350
RREKRKRALL
360
NLPGTQTSGE
370
AKDGPPKKQV
380
CGDSIKPEET
390
EQEVAADETR
400
NLPHSKQGNK
410
NDLEMGIKAA
420
RPEIADRATS
430
EVPGSQASPN
440
PVPGDGLHRA
450
GFDAFMTGYV
460
MAYVEVSQGP
470
QPCSSGPWLP
480
ECHNKVYLSG
490
KAVPLTVAKS
500
QFSRSSKAHN
510
QKMKLTWGSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Molecular Function | GO:0000175 | 3'-5'-RNA exonuclease activity |
| Molecular Function | GO:0004535 | poly(A)-specific ribonuclease activity |
| Molecular Function | GO:0017069 | snRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0034472 | snRNA 3'-end processing |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.