Search Results
Overview
| Uniprot ID | Q96GN5 |
|---|---|
| Protein Name | Cell division cycle-associated 7-like protein |
| Gene Name | CDCA7L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | VAFQFPTKKLANKPD |
| 152 | AFQFPTKKLANKPDK |
Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1
Protein Sequence
10
MELATRYQIP
20
KEVADIFNAP
30
SDDEEFVGFR
40
DDVPMETLSS
50
EESCDSFDSL
60
ESGKQQDVRF
70
HSKYFTEELR
80
RIFIEDTDSE
90
TEDFAGFTQS
100
DLNGKTNPEV
110
MVVESDLSDD
120
GKASLVSEEE
130
EDEEEDKATP
140
RRSRSRRSSI
150
GLRVAFQFPT
160
KKLANKPDKN
170
SSSEQLFSSA
180
RLQNEKKTIL
190
ERKKDCRQVI
200
QREDSTSESE
210
DDSRDESQES
220
SDALLKRTMN
230
IKENKAMLAQ
240
LLAELNSMPD
250
FFPVRTPTSA
260
SRKKTVRRAF
270
SEGQITRRMN
280
PTRSARPPEK
290
FALENFTVSA
300
AKFAEEFYSF
310
RRRKTIGGKC
320
REYRRRHRIS
330
SFRPVEDITE
340
EDLENVAITV
350
RDKIYDKVLG
360
NTCHQCRQKT
370
IDTKTVCRNQ
380
GCCGVRGQFC
390
GPCLRNRYGE
400
DVRSALLDPD
410
WVCPPCRGIC
420
NCSYCRKRDG
430
RCATGILIHL
440
AKFYGYDNVK
450
EYLESLQKEL
VEDN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
PMID: N/A