Search Results

Overview

Uniprot ID	Q96GX9
Protein Name	Methylthioribulose-1-phosphate dehydratase
Gene Name	APIP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
90	ISGPSPSKKLKKSQC

Function

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death

Protein Sequence

10 MSGCDAREGD 20 CCSRRCGAQD 30 KEHPRYLIPE 40 LCKQFYHLGW 50 VTGTGGGISL 60 KHGDEIYIAP 70 SGVQKERIQP 80 EDMFVCDINE 90 KDISGPSPSK 100 KLKKSQCTPL 110 FMNAYTMRGA 120 GAVIHTHSKA 130 AVMATLLFPG 140 REFKITHQEM 150 IKGIKKCTSG 160 GYYRYDDMLV 170 VPIIENTPEE 180 KDLKDRMAHA 190 MNEYPDSCAV 200 LVRRHGVYVW 210 GETWEKAKTM 220 CECYDYLFDI 230 AVSMKKVGLD 240 PSQLPVGENG IV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046570	methylthioribulose 1-phosphate dehydratase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0019509	L-methionine salvage from methylthioadenosine
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0051289	protein homotetramerization
Biological Process	GO:0070269	pyroptotic inflammatory response
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.