Search Results
Overview
| Uniprot ID | Q96H20 |
|---|---|
| Protein Name | Vacuolar-sorting protein SNF8 |
| Gene Name | SNF8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | VGAGAIAKKKLAEAK |
| 134 | QVLKGRGKFAQDVSQ |
| 14 | GAGAIAKKKLAEAKY |
| 20 | KKKLAEAKYKERGTV |
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy (PubMed:38423010). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045022 | early endosome to late endosome transport |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:1903543 | positive regulation of exosomal secretion |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:0043328 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0042176 | regulation of protein catabolic process |
| Biological Process | GO:0061635 | regulation of protein complex stability |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0000814 | ESCRT II complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0016247 | channel regulator activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.