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Overview

Uniprot IDQ96HA1
Protein NameNuclear envelope pore membrane protein POM 121
Gene NamePOM121
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
387 SSDDHLNKRSRSSSM
428 RGISQLWKRNGPSSS
507 SSGQRKRKVQLLPSR

Function

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)

Protein Sequence

10 MSPAAAAAGA 20 GERRRPIASV 30 RDGRGRGCGG 40 PARAVLLGLS 50 LVGLLLYLVP 60 AAAALAWLTV 70 GATAAWWGLS 80 REPRGSRPLS 90 SFVRKARHRR 100 PLSSFVRKAR 110 HRRTLFASPL 120 AKSTANGNLL 130 EPRTLLEGPD 140 PAELLLMGSY 150 LGKPGPPQPA 160 AAPEGQDLRD 170 RPGRRPPARP 180 APRSPPPRSP 190 PPRSPPPSPP 200 THRAHHVYPS 210 LPTPLLRPSR 220 RPSPRDCGTL 230 PNRFVITPRR 240 RYPIHQAQYS 250 CLGVLPTVCW 260 NGYHKKAVLS 270 PRNSRMVCSP 280 VTVRIAPPDR 290 RFSRSAIPEQ 300 IISSTLSSPS 310 SNAPDPCAKE 320 TVLSALKEKE 330 KKRTVEEEDQ 340 IFLDGQENKR 350 RRHDSSGSGH 360 SAFEPLVANG 370 VPASFVPKPG 380 SLKRGLNSQS 390 SDDHLNKRSR 400 SSSMSSLTGA 410 YASGIPSSSR 420 NAITSSYSST 430 RGISQLWKRN 440 GPSSSPFSSP 450 ASSRSQTPER 460 PAKKIREEEL 470 CHHSSSSTPL 480 AADRESQGEK 490 AADTTPRKKQ 500 NSNSQSTPGS 510 SGQRKRKVQL 520 LPSRRGEQLT 530 LPPPPQLGYS 540 ITAEDLDLEK 550 KASLQWFNQA 560 LEDKSDAASN 570 SVTETPPITQ 580 PSFTFTLPAA 590 APASPPTSLL 600 APSTNPLLES 610 LKKMQTPPSL 620 PPCPESAGAA 630 TTEALSPPKT 640 PSLLPPLGLS 650 QSGPPGLLPS 660 PSFDSKPPTT 670 LLGLIPAPSM 680 VPATDTKAPP 690 TLQAETATKP 700 QATSAPSPAP 710 KQSFLFGTQN 720 TSPSSPAAPA 730 ASSAPPMFKP 740 IFTAPPKSEK 750 EGPTPPGPSV 760 TATAPSSSSL 770 PTTTSTTAPT 780 FQPVFSSMGP 790 PASVPLPAPF 800 FKQTTTPATA 810 PTTTAPLFTG 820 LASATSAVAP 830 ITSASPSTDS 840 ASKPAFGFGI 850 NSVSSSSVST 860 TTSTATAASQ 870 PFLFGAPQAS 880 AASFTPAMGS 890 IFQFGKPPAL 900 PTTTTVTTFS 910 QSLHTAVPTA 920 TSSSAADFSG 930 FGSTLATSAP 940 ATSSQPTLTF 950 SNTSTPTFNI 960 PFGSSAKSPL 970 PSYPGANPQP 980 AFGAAEGQPP 990 GAAKPALAPS 1000 FGSSFTFGNS 1010 AAPAAAPTPA 1020 PPSMIKVVPA 1030 YVPTPIHPIF 1040 GGATHSAFGL 1050 KATASAFGAP 1060 ASSQPAFGGS 1070 TAVFFGAATS 1080 SGFGATTQTA 1090 SSGSSSSVFG 1100 STTPSPFTFG 1110 GSAAPAGSGS 1120 FGINVATPGS 1130 STTTGAFSFG 1140 AGQSGSTATS 1150 TPFAGGLGQN 1160 ALGTTGQSTP 1170 FAFNVSSTTE 1180 SKPVFGGTAT 1190 PTFGLNTPAP 1200 GVGTSGSSLS 1210 FGASSAPAQG 1220 FVGVAPFGSA 1230 ALSFSIGAGS 1240 KTPGARQRLQ ARRQHTRKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0017056 structural constituent of nuclear pore
Biological Process GO:0051028 mRNA transport
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.