Search Results

Overview

Uniprot IDQ96HC4
Protein NamePDZ and LIM domain protein 5
Gene NamePDLIM5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
116 ITSPAVSKVTSTNNM
127 TNNMAYNKAPRPFGS
233 RGSQGDSKQQNGPPR
261 PTHSDASKKRLIEDT
262 THSDASKKRLIEDTE
296 ITGTEHLKESEADNT
415 AEHIPAGKRTPMCAH
495 GEVISALKQTWHVSC
589 KDKPLCKKHAHSVNF
97 PEPVPVQKGEPKEVV

Function

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation

Protein Sequence

10 MSNYSVSLVG 20 PAPWGFRLQG 30 GKDFNMPLTI 40 SSLKDGGKAA 50 QANVRIGDVV 60 LSIDGINAQG 70 MTHLEAQNKI 80 KGCTGSLNMT 90 LQRASAAPKP 100 EPVPVQKGEP 110 KEVVKPVPIT 120 SPAVSKVTST 130 NNMAYNKAPR 140 PFGSVSSPKV 150 TSIPSPSSAF 160 TPAHATTSSH 170 ASPSPVAAVT 180 PPLFAASGLH 190 ANANLSADQS 200 PSALSAGKTA 210 VNVPRQPTVT 220 SVCSETSQEL 230 AEGQRRGSQG 240 DSKQQNGPPR 250 KHIVERYTEF 260 YHVPTHSDAS 270 KKRLIEDTED 280 WRPRTGTTQS 290 RSFRILAQIT 300 GTEHLKESEA 310 DNTKKANNSQ 320 EPSPQLASSV 330 ASTRSMPESL 340 DSPTSGRPGV 350 TSLTAAAAFK 360 PVGSTGVIKS 370 PSWQRPNQGV 380 PSTGRISNSA 390 TYSGSVAPAN 400 SALGQTQPSD 410 QDTLVQRAEH 420 IPAGKRTPMC 430 AHCNQVIRGP 440 FLVALGKSWH 450 PEEFNCAHCK 460 NTMAYIGFVE 470 EKGALYCELC 480 YEKFFAPECG 490 RCQRKILGEV 500 ISALKQTWHV 510 SCFVCVACGK 520 PIRNNVFHLE 530 DGEPYCETDY 540 YALFGTICHG 550 CEFPIEAGDM 560 FLEALGYTWH 570 DTCFVCSVCC 580 ESLEGQTFFS 590 KKDKPLCKKH AHSVNF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Molecular Function GO:0042805 actinin binding
Molecular Function GO:0098641 cadherin binding involved in cell-cell adhesion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051371 muscle alpha-actinin binding
Molecular Function GO:0005080 protein kinase C binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0061049 cell growth involved in cardiac muscle cell development
Biological Process GO:0007507 heart development
Biological Process GO:0061061 muscle structure development
Biological Process GO:0061001 regulation of dendritic spine morphogenesis
Biological Process GO:0051963 regulation of synapse assembly
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0016020 membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0098793 presynapse
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.