Overview
| Uniprot ID | Q96HE7 |
|---|
| Protein Name | ERO1-like protein alpha |
|---|
| Gene Name | ERO1A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 244 |
LEGLCVEKRAFYRLI |
| 275 |
LQETWLEKKWGHNIT |
Function
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed:29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin
Protein Sequence
10
MGRGWGFLFG
20
LLGAVWLLSS
30
GHGEEQPPET
40
AAQRCFCQVS
50
GYLDDCTCDV
60
ETIDRFNNYR
70
LFPRLQKLLE
80
SDYFRYYKVN
90
LKRPCPFWND
100
ISQCGRRDCA
110
VKPCQSDEVP
120
DGIKSASYKY
130
SEEANNLIEE
140
CEQAERLGAV
150
DESLSEETQK
160
AVLQWTKHDD
170
SSDNFCEADD
180
IQSPEAEYVD
190
LLLNPERYTG
200
YKGPDAWKIW
210
NVIYEENCFK
220
PQTIKRPLNP
230
LASGQGTSEE
240
NTFYSWLEGL
250
CVEKRAFYRL
260
ISGLHASINV
270
HLSARYLLQE
280
TWLEKKWGHN
290
ITEFQQRFDG
300
ILTEGEGPRR
310
LKNLYFLYLI
320
ELRALSKVLP
330
FFERPDFQLF
340
TGNKIQDEEN
350
KMLLLEILHE
360
IKSFPLHFDE
370
NSFFAGDKKE
380
AHKLKEDFRL
390
HFRNISRIMD
400
CVGCFKCRLW
410
GKLQTQGLGT
420
ALKILFSEKL
430
IANMPESGPS
440
YEFHLTRQEI
450
VSLFNAFGRI
460
STSVKELENF
RNLLQNIH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005796 |
Golgi lumen |
| Cellular Component |
GO:0043231 |
intracellular membrane-bounded organelle |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0071949 |
FAD binding |
| Molecular Function |
GO:0016971 |
flavin-dependent sulfhydryl oxidase activity |
| Molecular Function |
GO:0015035 |
protein-disulfide reductase activity |
| Molecular Function |
GO:0016972 |
thiol oxidase activity |
| Biological Process |
GO:0045454 |
cell redox homeostasis |
| Biological Process |
GO:0071456 |
cellular response to hypoxia |
| Biological Process |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0034975 |
protein folding in endoplasmic reticulum |
| Biological Process |
GO:0051209 |
release of sequestered calcium ion into cytosol |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0009266 |
response to temperature stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.