Search Results
Overview
| Uniprot ID | Q96I15 |
|---|---|
| Protein Name | Selenocysteine lyase |
| Gene Name | SCLY |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | SQPSGCGKHNSPERK |
| 341 | LEAEFGQKRIHLNSQ |
Function
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium
Protein Sequence
10
MEAAVAPGRD
20
APAPAASQPS
30
GCGKHNSPER
40
KVYMDYNATT
50
PLEPEVIQAM
60
TKAMWEAWGN
70
PSSPYSAGRK
80
AKDIINAARE
90
SLAKMIGGKP
100
QDIIFTSGGT
110
ESNNLVIHSV
120
VKHFHANQTS
130
KGHTGGHHSP
140
VKGAKPHFIT
150
SSVEHDSIRL
160
PLEHLVEEQV
170
AAVTFVPVSK
180
VSGQAEVDDI
190
LAAVRPTTRL
200
VTIMLANNET
210
GIVMPVPEIS
220
QRIKALNQER
230
VAAGLPPILV
240
HTDAAQALGK
250
QRVDVEDLGV
260
DFLTIVGHKF
270
YGPRIGALYI
280
RGLGEFTPLY
290
PMLFGGGQER
300
NFRPGTENTP
310
MIAGLGKAAE
320
LVTQNCEAYE
330
AHMRDVRDYL
340
EERLEAEFGQ
350
KRIHLNSQFP
360
GTQRLPNTCN
370
FSIRGPRLQG
380
HVVLAQCRVL
390
MASVGAACHS
400
DHGDQPSPVL
410
LSYGVPFDVA
420
RNALRLSVGR
430
STTRAEVDLV
440
VQDLKQAVAQ
LEDQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902494 | catalytic complex |
| Molecular Function | GO:0016740 | transferase activity |
| Molecular Function | GO:0070279 | vitamin B6 binding |
| Biological Process | GO:0006520 | amino acid metabolic process |
| Biological Process | GO:0016261 | selenocysteine catabolic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0009000 | selenocysteine lyase activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.