Search Results
Overview
| Uniprot ID | Q96I59 |
|---|---|
| Protein Name | Asparaginyl-tRNA synthetase |
| Gene Name | NARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 353 | DLRTEHEKYLVKHCG |
Function
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis (PubMed:25385316). The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (Probable)
Protein Sequence
10
MLGVRCLLRS
20
VRFCSSAPFP
30
KHKPSAKLSV
40
RDALGAQNAS
50
GERIKIQGWI
60
RSVRSQKEVL
70
FLHVNDGSSL
80
ESLQVVADSG
90
LDSRELNFGS
100
SVEVQGQLIK
110
SPSKRQNVEL
120
KAEKIKVIGN
130
CDAKDFPIKY
140
KERHPLEYLR
150
QYPHFRCRTN
160
VLGSILRIRS
170
EATAAIHSFF
180
KDSGFVHIHT
190
PIITSNDSEG
200
AGELFQLEPS
210
GKLKVPEENF
220
FNVPAFLTVS
230
GQLHLEVMSG
240
AFTQVFTFGP
250
TFRAENSQSR
260
RHLAEFYMIE
270
AEISFVDSLQ
280
DLMQVIEELF
290
KATTMMVLSK
300
CPEDVELCHK
310
FIAPGQKDRL
320
EHMLKNNFLI
330
ISYTEAVEIL
340
KQASQNFTFT
350
PEWGADLRTE
360
HEKYLVKHCG
370
NIPVFVINYP
380
LTLKPFYMRD
390
NEDGPQHTVA
400
AVDLLVPGVG
410
ELFGGGLREE
420
RYHFLEERLA
430
RSGLTEVYQW
440
YLDLRRFGSV
450
PHGGFGMGFE
460
RYLQCILGVD
470
NIKDVIPFPR
FPHSCLL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004816 | asparagine-tRNA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Biological Process | GO:0006421 | asparaginyl-tRNA aminoacylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.