Overview
| Uniprot ID | Q96IX5 |
|---|
| Protein Name | ATP synthase F(0) complex subunit k, mitochondrial |
|---|
| Gene Name | ATP5MK |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 16 |
QYQFTGIKKYFNSYT |
Function
Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (By similarity). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (PubMed:21345788, PubMed:29917077)
Protein Sequence
10
MAGPESDAQY
20
QFTGIKKYFN
30
SYTLTGRMNC
40
VLATYGSIAL
50
IVLYFKLRSK
KTPAVKAT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.