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Overview

Uniprot IDQ96IZ0
Protein NamePRKC apoptosis WT1 regulator protein
Gene NamePAWR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
227 RTVSGRYKSTTSVSE

Function

Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1

Protein Sequence

10 MATGGYRTSS 20 GLGGSTTDFL 30 EEWKAKREKM 40 RAKQNPPGPA 50 PPGGGSSDAA 60 GKPPAGALGT 70 PAAAAANELN 80 NNLPGGAPAA 90 PAVPGPGGVN 100 CAVGSAMLTR 110 AAPGPRRSED 120 EPPAASASAA 130 PPPQRDEEEP 140 DGVPEKGKSS 150 GPSARKGKGQ 160 IEKRKLREKR 170 RSTGVVNIPA 180 AECLDEYEDD 190 EAGQKERKRE 200 DAITQQNTIQ 210 NEAVNLLDPG 220 SSYLLQEPPR 230 TVSGRYKSTT 240 SVSEEDVSSR 250 YSRTDRSGFP 260 RYNRDANVSG 270 TLVSSSTLEK 280 KIEDLEKEVV 290 RERQENLRLV 300 RLMQDKEEMI 310 GKLKEEIDLL 320 NRDLDDIEDE 330 NEQLKQENKT 340 LLKVVGQLTR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:2000774 positive regulation of cellular senescence
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003779 actin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0043522 leucine zipper domain binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0006915 apoptotic process
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0048147 negative regulation of fibroblast proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043065 positive regulation of apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.