Search Results

Overview

Uniprot IDQ96JB3
Protein NameHypermethylated in cancer 2 protein
Gene NameHIC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
183 QGLVDGRKGAHAPQE

Function

Transcriptional repressor

Protein Sequence

10 MVSGPLALRW 20 CAWAGRGDMG 30 PDMELPSHSK 40 QLLLQLNQQR 50 TKGFLCDVII 60 MVENSIFRAH 70 KNVLAASSIY 80 FKSLVLHDNL 90 INLDTDMVSS 100 TVFQQILDFI 110 YTGKLLPSDQ 120 PAEPNFSTLL 130 TAASYLQLPE 140 LAALCRRKLK 150 RAGKPFGSGR 160 AGSTGMGRPP 170 RSQRLSTASV 180 IQARYQGLVD 190 GRKGAHAPQE 200 LPQAKGSDDE 210 LFLGGSNQDS 220 VQGLGRAVCP 230 AGGEAGLGGC 240 SSSTNGSSGG 250 CEQELGLDLS 260 KKSPPLPPAT 270 PGPHLTPDDA 280 AQLSDSQHGS 290 PPAASAPPVA 300 NSASYSELGG 310 TPDEPMDLEG 320 AEDNHLSLLE 330 APGGQPRKSL 340 RHSTRKKEWG 350 KKEPVAGSPF 360 ERREAGPKGP 370 CPGEEGEGVG 380 DRVPNGILAS 390 GAGPSGPYGE 400 PPYPCKEEEE 410 NGKDASEDSA 420 QSGSEGGSGH 430 ASAHYMYRQE 440 GYETVSYGDN 450 LYVCIPCAKG 460 FPSSEQLNAH 470 VETHTEEELF 480 IKEEGAYETG 490 SGGAEEEAED 500 LSAPSAAYTA 510 EPRPFKCSVC 520 EKTYKDPATL 530 RQHEKTHWLT 540 RPFPCNICGK 550 MFTQRGTMTR 560 HMRSHLGLKP 570 FACDECGMRF 580 TRQYRLTEHM 590 RVHSGEKPYE 600 CQLCGGKFTQ 610 QRNLISHLRM HTSPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001817 regulation of cytokine production
Biological Process GO:0002682 regulation of immune system process

Reference

PMID: N/A