Search Results

Overview

Uniprot IDQ96JC9
Protein NameELL-associated factor 1
Gene NameEAF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 SSSIQVKKTRAEGSS
118 TRAEGSSKIQARMEQ

Function

Acts as a transcriptional transactivator of ELL and ELL2 elongation activities

Protein Sequence

10 MNGTANPLLD 20 REEHCLRLGE 30 SFEKRPRASF 40 HTIRYDFKPA 50 SIDTSCEGEL 60 QVGKGDEVTI 70 TLPHIPGSTP 80 PMTVFKGNKR 90 PYQKDCVLII 100 NHDTGEYVLE 110 KLSSSIQVKK 120 TRAEGSSKIQ 130 ARMEQQPTRP 140 PQTSQPPPPP 150 PPMPFRAPTK 160 PPVGPKTSPL 170 KDNPSPEPQL 180 DDIKRELRAE 190 VDIIEQMSSS 200 SGSSSSDSES 210 SSGSDDDSSS 220 SGGEDNGPAS 230 PPQPSHQQPY 240 NSRPAVANGT 250 SRPQGSNQLM 260 NTLRNDLQLS ESGSDSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032783 super elongation complex
Cellular Component GO:0008023 transcription elongation factor complex
Molecular Function GO:0003711 transcription elongation factor activity
Biological Process GO:0034243 regulation of transcription elongation by RNA polymerase II
Biological Process GO:0006368 transcription elongation by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.