Search Results

Overview

Uniprot IDQ96JE9
Protein NameMicrotubule-associated protein 6
Gene NameMAP6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
229 AGGLAAGKASGADER
450 QPVSDSSKTQGPVAT
549 PMVPAKVKDQGSVVP
769 PLVPVPAKDQGPAVP

Function

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity)

Protein Sequence

10 MAWPCITRAC 20 CIARFWNQLD 30 KADIAVPLVF 40 TKYSEATEHP 50 GAPPQPPPPQ 60 QQAQPALAPP 70 SARAVAIETQ 80 PAQGELDAVA 90 RATGPAPGPT 100 GEREPAAGPG 110 RSGPGPGLGS 120 GSTSGPADSV 130 MRQDYRAWKV 140 QRPEPSCRPR 150 SEYQPSDAPF 160 ERETQYQKDF 170 RAWPLPRRGD 180 HPWIPKPVQI 190 SAASQASAPI 200 LGAPKRRPQS 210 QERWPVQAAA 220 EAREQEAAPG 230 GAGGLAAGKA 240 SGADERDTRR 250 KAGPAWIVRR 260 AEGLGHEQTP 270 LPAAQAQVQA 280 TGPEAGRGRA 290 AADALNRQIR 300 EEVASAVSSS 310 YRNEFRAWTD 320 IKPVKPIKAK 330 PQYKPPDDKM 340 VHETSYSAQF 350 KGEASKPTTA 360 DNKVIDRRRI 370 RSLYSEPFKE 380 PPKVEKPSVQ 390 SSKPKKTSAS 400 HKPTRKAKDK 410 QAVSGQAAKK 420 KSAEGPSTTK 430 PDDKEQSKEM 440 NNKLAEAKES 450 LAQPVSDSSK 460 TQGPVATEPD 470 KDQGSVVPGL 480 LKGQGPMVQE 490 PLKKQGSVVP 500 GPPKDLGPMI 510 PLPVKDQDHT 520 VPEPLKNESP 530 VISAPVKDQG 540 PSVPVPPKNQ 550 SPMVPAKVKD 560 QGSVVPESLK 570 DQGPRIPEPV 580 KNQAPMVPAP 590 VKDEGPMVSA 600 SVKDQGPMVS 610 APVKDQGPIV 620 PAPVKGEGPI 630 VPAPVKDEGP 640 MVSAPIKDQD 650 PMVPEHPKDE 660 SAMATAPIKN 670 QGSMVSEPVK 680 NQGLVVSGPV 690 KDQDVVVPEH 700 AKVHDSAVVA 710 PVKNQGPVVP 720 ESVKNQDPIL 730 PVLVKDQGPT 740 VLQPPKNQGR 750 IVPEPLKNQV 760 PIVPVPLKDQ 770 DPLVPVPAKD 780 QGPAVPEPLK 790 TQGPRDPQLP 800 TVSPLPRVMI 810 PTAPHTEYIE SSP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005801 cis-Golgi network
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005798 Golgi-associated vesicle
Cellular Component GO:0005874 microtubule
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0030658 transport vesicle membrane
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0048813 dendrite morphogenesis
Biological Process GO:0032418 lysosome localization
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0070507 regulation of microtubule cytoskeleton organization

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.