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Overview

Uniprot IDQ96JG8
Protein NameMelanoma-associated antigen D4
Gene NameMAGED4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
287 EVAATRPKTTKSGKA

Function

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex

Protein Sequence

10 MAEGSFSVQS 20 ESYSVEDMDE 30 GSDEVGEEEM 40 VEGNDYEEFG 50 AFGGYGTLTS 60 FDIHILRAFG 70 SLGPGLRILS 80 NEPWELENPV 90 LAQTLVEALQ 100 LDPETLANET 110 AARAANVARA 120 AASNRAARAA 130 AAAARTAFSQ 140 VVASHRVATP 150 QVSGEDTQPT 160 TYAAEAQGPT 170 PEPPLASPQT 180 SQMLVTSKMA 190 APEAPATSAQ 200 SQTGSPAQEA 210 ATEGPSSACA 220 FSQAPCAREV 230 DANRPSTAFL 240 GQNDVFDFTQ 250 PAGVSGMAFP 260 RPKRPAPAQE 270 AATEGPSAAS 280 GVPQTGPGRE 290 VAATRPKTTK 300 SGKALAKTRW 310 VEPQNVVAAA 320 AAKAKMATSI 330 PEPEGAAAAT 340 AQHSAEPWAR 350 MGGKRTKKSK 360 HLDDEYESSE 370 EERETPAVPP 380 TWRASQPSLT 390 VRAQLAPRPP 400 MAPRSQIPSR 410 HVLCLPPRNV 420 TLLQERANKL 430 VKYLMIKDYK 440 KIPIKRADML 450 KDVIREYDEH 460 FPEIIERATY 470 TLEKKFGIHL 480 KEIDKEEHLY 490 ILVCTRDSSA 500 RLLGKTKDTP 510 RLSLLLVILG 520 VIFMNGNRAS 530 EAVLWEALRK 540 MGLRPGVRHP 550 FLGDLRKLIT 560 DDFVKQKYLE 570 YKKIPNSNPP 580 EYEFLWGLRA 590 RHETSKMRVL 600 RFIAQNQNRD 610 PREWKAHFLE 620 AVDDAFKTMD 630 VDMAEEHARA 640 QMRAQMNIGD 650 EALIGRWSWD 660 DIQVELLTWD 670 EDGDFGDAWA 680 RIPFAFWARY 690 HQYILNSNRA 700 NRRATWRAGV 710 SSGTNGGAST 720 SVLDGPSTSS 730 TIRTRNAARA 740 GASFFSWIQH R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

PMID: N/A