Overview
| Uniprot ID | Q96JH7 |
|---|
| Protein Name | Deubiquitinating protein VCPIP1 |
|---|
| Gene Name | VCPIP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 740 |
EKLKQEQKGQPRTVS |
Function
Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681)
Protein Sequence
10
MSQPPPPPPP
20
LPPPPPPPEA
30
PQTPSSLASA
40
AASGGLLKRR
50
DRRILSGSCP
60
DPKCQARLFF
70
PASGSVSIEC
80
TECGQRHEQQ
90
QLLGVEEVTD
100
PDVVLHNLLR
110
NALLGVTGAP
120
KKNTELVKVM
130
GLSNYHCKLL
140
SPILARYGMD
150
KQTGRAKLLR
160
DMNQGELFDC
170
ALLGDRAFLI
180
EPEHVNTVGY
190
GKDRSGSLLY
200
LHDTLEDIKR
210
ANKSQECLIP
220
VHVDGDGHCL
230
VHAVSRALVG
240
RELFWHALRE
250
NLKQHFQQHL
260
ARYQALFHDF
270
IDAAEWEDII
280
NECDPLFVPP
290
EGVPLGLRNI
300
HIFGLANVLH
310
RPIILLDSLS
320
GMRSSGDYSA
330
TFLPGLIPAE
340
KCTGKDGHLN
350
KPICIAWSSS
360
GRNHYIPLVG
370
IKGAALPKLP
380
MNLLPKAWGV
390
PQDLIKKYIK
400
LEEDGGCVIG
410
GDRSLQDKYL
420
LRLVAAMEEV
430
FMDKHGIHPS
440
LVADVHQYFY
450
RRTGVIGVQP
460
EEVTAAAKKA
470
VMDNRLHKCL
480
LCGALSELHV
490
PPEWLAPGGK
500
LYNLAKSTHG
510
QLRTDKNYSF
520
PLNNLVCSYD
530
SVKDVLVPDY
540
GMSNLTACNW
550
CHGTSVRKVR
560
GDGSIVYLDG
570
DRTNSRSTGG
580
KCGCGFKHFW
590
DGKEYDNLPE
600
AFPITLEWGG
610
RVVRETVYWF
620
QYESDSSLNS
630
NVYDVAMKLV
640
TKHFPGEFGS
650
EILVQKVVHT
660
ILHQTAKKNP
670
DDYTPVNIDG
680
AHAQRVGDVQ
690
GQESESQLPT
700
KIILTGQKTK
710
TLHKEELNMS
720
KTERTIQQNI
730
TEQASVMQKR
740
KTEKLKQEQK
750
GQPRTVSPST
760
IRDGPSSAPA
770
TPTKAPYSPT
780
TSKEKKIRIT
790
TNDGRQSMVT
800
LKSSTTFFEL
810
QESIAREFNI
820
PPYLQCIRYG
830
FPPKELMPPQ
840
AGMEKEPVPL
850
QHGDRITIEI
860
LKSKAEGGQS
870
AAAHSAHTVK
880
QEDIAVTGKL
890
SSKELQEQAE
900
KEMYSLCLLA
910
TLMGEDVWSY
920
AKGLPHMFQQ
930
GGVFYSIMKK
940
TMGMADGKHC
950
TFPHLPGKTF
960
VYNASEDRLE
970
LCVDAAGHFP
980
IGPDVEDLVK
990
EAVSQVRAEA
1000
TTRSRESSPS
1010
HGLLKLGSGG
1020
VVKKKSEQLH
1030
NVTAFQGKGH
1040
SLGTASGNPH
1050
LDPRARETSV
1060
VRKHNTGTDF
1070
SNSSTKTEPS
1080
VFTASSSNSE
1090
LIRIAPGVVT
1100
MRDGRQLDPD
1110
LVEAQRKKLQ
1120
EMVSSIQASM
1130
DRHLRDQSTE
1140
QSPSDLPQRK
1150
TEVVSSSAKS
1160
GSLQTGLPES
1170
FPLTGGTENL
1180
NTETTDGCVA
1190
DALGAAFATR
1200
SKAQRGNSVE
1210
ELEEMDSQDA
1220
EMTNTTEPMD
HS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0004843 |
cysteine-type deubiquitinase activity |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0016320 |
endoplasmic reticulum membrane fusion |
| Biological Process |
GO:0090168 |
Golgi reassembly |
| Biological Process |
GO:0016579 |
protein deubiquitination |
| Biological Process |
GO:0035871 |
protein K11-linked deubiquitination |
| Biological Process |
GO:0071108 |
protein K48-linked deubiquitination |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0043335 |
protein unfolding |
| Biological Process |
GO:0106300 |
protein-DNA covalent cross-linking repair |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:1905634 |
regulation of protein localization to chromatin |
Reference
PMID: N/A