Search Results
Overview
| Uniprot ID | Q96JJ3 |
|---|---|
| Protein Name | Engulfment and cell motility protein 2 |
| Gene Name | ELMO2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 577 | CRLALNHKVLHYGDL |
Function
Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs) (PubMed:11595183, PubMed:11703939, PubMed:20679435, PubMed:32651375, PubMed:27476657). Acts in association with DOCK1, DOCK2, DOCK4 and CRK (PubMed:11595183, PubMed:20679435, PubMed:32651375, PubMed:27476657). Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility (PubMed:11595183)
Protein Sequence
10
MPPPSDIVKV
20
AIEWPGANAQ
30
LLEIDQKRPL
40
ASIIKEVCDG
50
WSLPNPEYYT
60
LRYADGPQLY
70
ITEQTRSDIK
80
NGTILQLAIS
90
PSRAARQLME
100
RTQSSNMETR
110
LDAMKELAKL
120
SADVTFATEF
130
INMDGIIVLT
140
RLVESGTKLL
150
SHYSEMLAFT
160
LTAFLELMDH
170
GIVSWDMVSI
180
TFIKQIAGYV
190
SQPMVDVSIL
200
QRSLAILESM
210
VLNSQSLYQK
220
IAEEITVGQL
230
ISHLQVSNQE
240
IQTYAIALIN
250
ALFLKAPEDK
260
RQDMANAFAQ
270
KHLRSIILNH
280
VIRGNRPIKT
290
EMAHQLYVLQ
300
VLTFNLLEER
310
MMTKMDPNDQ
320
AQRDIIFELR
330
RIAFDAESDP
340
SNAPGSGTEK
350
RKAMYTKDYK
360
MLGFTNHINP
370
AMDFTQTPPG
380
MLALDNMLYL
390
AKVHQDTYIR
400
IVLENSSRED
410
KHECPFGRSA
420
IELTKMLCEI
430
LQVGELPNEG
440
RNDYHPMFFT
450
HDRAFEELFG
460
ICIQLLNKTW
470
KEMRATAEDF
480
NKVMQVVREQ
490
ITRALPSKPN
500
SLDQFKSKLR
510
SLSYSEILRL
520
RQSERMSQDD
530
FQSPPIVELR
540
EKIQPEILEL
550
IKQQRLNRLC
560
EGSSFRKIGN
570
RRRQERFWYC
580
RLALNHKVLH
590
YGDLDDNPQG
600
EVTFESLQEK
610
IPVADIKAIV
620
TGKDCPHMKE
630
KSALKQNKEV
640
LELAFSILYD
650
PDETLNFIAP
660
NKYEYCIWID
670
GLSALLGKDM
680
SSELTKSDLD
690
TLLSMEMKLR
700
LLDLENIQIP
710
EAPPPIPKEP
720
SSYDFVYHYG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:2001212 | regulation of vasculogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.