Search Results

Overview

Uniprot IDQ96JM2
Protein NameZinc finger protein 462
Gene NameZNF462
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1006 GLPATFNKNTPKTFT
106 ANPKPTNKFFQCKFC
1571 EETSRIFKQGYGAYR
428 GNKLLETKGIPFRRF
657 SSSNTVKKSQTSILG
668 SILGLSSKNNFVAKA
674 SKNNFVAKASRKLAN

Function

Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965)

Protein Sequence

10 MEVLQCDGCD 20 FRAPSYEDLK 30 AHIQDVHTAF 40 LQPTDVAEDN 50 VNELRCGSVN 60 ASNQTEVEFS 70 SIKDEFAIAE 80 DLSGQNATSL 90 GTGGYYGHSP 100 GYYGQHIAAN 110 PKPTNKFFQC 120 KFCVRYFRSK 130 NLLIEHTRKV 140 HGAQAEGSSS 150 GPPVPGSLNY 160 NIMMHEGFGK 170 VFSCQFCTYK 180 SPRRARIIKH 190 QKMYHKNNLK 200 ETTAPPPAPA 210 PMPDPVVPPV 220 SLQDPCKELP 230 AEVVERSILE 240 SMVKPLTKSR 250 GNFCCEWCSY 260 QTPRRERWCD 270 HMMKKHRSMV 280 KILSSLRQQQ 290 EGTNLPDVPN 300 KSAPSPTSNS 310 TYLTMNAASR 320 EIPNTTVSNF 330 RGSMGNSIMR 340 PNSSASKFSP 350 MSYPQMKPKS 360 PHNSGLVNLT 370 ERSRYGMTDM 380 TNSSADLETN 390 SMLNDSSSDE 400 ELNEIDSENG 410 LSAMDHQTSG 420 LSAEQLMGSD 430 GNKLLETKGI 440 PFRRFMNRFQ 450 CPFCPFLTMH 460 RRSISRHIEN 470 IHLSGKTAVY 480 KCDECPFTCK 490 SSLKLGAHKQ 500 CHTGTTSDWD 510 AVNSQSESIS 520 SSLNEGVVSY 530 ESSSINGRKS 540 GVMLDPLQQQ 550 QPPQPPPPPP 560 PPPPSQPQPL 570 QQPQPPQLQP 580 PHQVPPQPQT 590 QPPPTQQPQP 600 PTQAAPLHPY 610 KCTMCNYSTT 620 TLKGLRVHQQ 630 HKHSFCDNLP 640 KFEGQPSSLP 650 LENETDSHPS 660 SSNTVKKSQT 670 SILGLSSKNN 680 FVAKASRKLA 690 NDFPLDLSPV 700 KKRTRIDEIA 710 SNLQSKINQT 720 KQQEDAVINV 730 EDDEEEEEDN 740 EVEIEVELDR 750 EEEPTEPIIE 760 VPTSFSAQQI 770 WVRDTSEPQK 780 EPNFRNITHD 790 YNATNGAEIE 800 LTLSEDEEDY 810 YGSSTNLKDH 820 QVSNTALLNT 830 QTPIYGTEHN 840 SENTDFGDSG 850 RLYYCKHCDF 860 NNKSARSVST 870 HYQRMHPYIK 880 FSFRYILDPN 890 DHSAVYRCLE 900 CYIDYTNFED 910 LQQHYGEHHP 920 EAMNVLNFDH 930 SDLIYRCRFC 940 SYTSPNVRSL 950 MPHYQRMHPT 960 VKINNAMIFS 970 SYVVEQQEGL 980 NTESQTLREI 990 LNSAPKNMAT 1000 STPVARGGGL 1010 PATFNKNTPK 1020 TFTPECENQK 1030 DPLVNTVVVY 1040 DCDVCSFASP 1050 NMHSVLVHYQ 1060 KKHPEEKASY 1070 FRIQKTMRMV 1080 SVDRGSALSQ 1090 LSFEVGAPMS 1100 PKMSNMGSPP 1110 PPQPPPPDLS 1120 TELYYCKHCS 1130 YSNRSVVGVL 1140 VHYQKRHPEI 1150 KVTAKYIRQA 1160 PPTAAMMRGV 1170 EGPQGSPRPP 1180 APIQQLNRSS 1190 SERDGPPVEN 1200 EMFFCQHCDY 1210 GNRTVKGVLI 1220 HYQKKHRDFK 1230 ANADVIRQHT 1240 ATIRSLCDRN 1250 QKKPASCVLV 1260 SPSNLERDKT 1270 KLRALKCRQC 1280 SYTSPYFYAL 1290 RKHIKKDHPA 1300 LKATVTSIMR 1310 WAFLDGLIEA 1320 GYHCEWCIYS 1330 HTEPNGLLLH 1340 YQRRHPEHYV 1350 DYTYMATKLW 1360 AGPDPSPPSL 1370 TMPAEAKTYR 1380 CRDCVFEAVS 1390 IWDITNHYQA 1400 FHPWAMNGDE 1410 SVLLDIIKEK 1420 DAVEKPILSS 1430 EELAGPVNCE 1440 NSIPTPFPEQ 1450 EAECPEDARL 1460 SPEKSLQLAS 1470 ANPAISSTPY 1480 QCTVCQSEYN 1490 NLHGLLTHYG 1500 KKHPGMKVKA 1510 ADFAQDIDIN 1520 PGAVYKCRHC 1530 PYINTRIHGV 1540 LTHYQKRHPS 1550 IKVTAEDFVH 1560 DVEQSADISQ 1570 NDVEETSRIF 1580 KQGYGAYRCK 1590 LCPYTHGTLE 1600 KLKIHYEKYH 1610 NQPEFDVFSQ 1620 SPPKLPVPLE 1630 PEMTTEVSPS 1640 QVSITEEEVG 1650 EEPVSTSHFS 1660 TSHLVSHTVF 1670 RCQLCKYFCS 1680 TRKGIARHYR 1690 IKHNNVRAQP 1700 EGKNNLFKCA 1710 LCAYTNPIRK 1720 GLAAHYQKRH 1730 DIDAYYTHCL 1740 AASRTISDKP 1750 NKVIIPSPPK 1760 DDSPQLSEEL 1770 RRAVEKKKCS 1780 LCSFQSFSKK 1790 GIVSHYMKRH 1800 PGVFPKKQHA 1810 SKLGGYFTAV 1820 YADEHEKPTL 1830 MEEEERGNFE 1840 KAEVEGEAQE 1850 IEWLPFRCIK 1860 CFKLSFSTAE 1870 LLCMHYTDHH 1880 SRDLKRDFII 1890 LGNGPRLQNS 1900 TYQCKHCDSK 1910 LQSTAELTSH 1920 LNIHNEEFQK 1930 RAKRQERRKQ 1940 LLSKQKYADG 1950 AFADFKQERP 1960 FGHLEEVPKI 1970 KERKVVGYKC 1980 KFCVEVHPTL 1990 RAICNHLRKH 2000 VQYGNVPAVS 2010 AAVKGLRSHE 2020 RSHLALAMFT 2030 REDKYSCQYC 2040 SFVSAFRHNL 2050 DRHMQTHHGH 2060 HKPFRCKLCS 2070 FKSSYNSRLK 2080 THILKAHAGE 2090 HAYKCSWCSF 2100 STMTISQLKE 2110 HSLKVHGKAL 2120 TLPRPRIVSL 2130 LSSHSHHSSQ 2140 KATPAEEVED 2150 SNDSSYSEPP 2160 DVQQQLNHYQ 2170 SAALARNNSR 2180 VSPVPLSGAA 2190 AGTEQKTEAV 2200 LHCEFCEFSS 2210 GYIQSIRRHY 2220 RDKHGGKKLF 2230 KCKDCSFYTG 2240 FKSAFTMHVE 2250 AGHSAVPEEG 2260 PKDLRCPLCL 2270 YHTKYKRNMI 2280 DHIVLHREER 2290 VVPIEVCRSK 2300 LSKYLQGVVF 2310 RCDKCTFTCS 2320 SDESLQQHIE 2330 KHNELKPYKC 2340 QLCYYETKHT 2350 EELDSHLRDE 2360 HKVSRNFELV 2370 GRVNLDQLEQ 2380 MKEKMESSSS 2390 DDEDKEEEMN 2400 SKAEDRELMR 2410 FSDHGAALNT 2420 EKRFPCEFCG 2430 RAFSQGSEWE 2440 RHVLRHGMAL 2450 NDTKQVSREE 2460 IHPKEIMENS 2470 VKMPSIEEKE 2480 DDEAIGIDFS 2490 LKNETVAICV 2500 VTADKSLLEN AEAKKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.