Search Results

Overview

Uniprot IDQ96JM3
Protein NameChromosome alignment-maintaining phosphoprotein 1
Gene NameCHAMP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
116 PPLPEHQKIPCNSAE
324 PGSPRPWKSNPSASS
381 SVSPSSWKSPPASPE
391 PASPESWKSGPPELR
399 SGPPELRKTAPTLSP
556 ALFPEPRKHALFPEL
617 DTLFPSSKKLKKDNQ
618 TLFPSSKKLKKDNQE
621 PSSKKLKKDNQESSD
90 SKHASPDKWNDKPKN

Function

Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore

Protein Sequence

10 MEAFQELRKP 20 SARLECDHCS 30 FRGTDYENVQ 40 IHMGTIHPEF 50 CDEMDAGGLG 60 KMIFYQKSAK 70 LFHCHKCFFT 80 SKMYSNVYYH 90 ITSKHASPDK 100 WNDKPKNQLN 110 KETDPVKSPP 120 LPEHQKIPCN 130 SAEPKSIPAL 140 SMETQKLGSV 150 LSPESPKPTP 160 LTPLEPQKPG 170 SVVSPELQTP 180 LPSPEPSKPA 190 SVSSPEPPKS 200 VPVCESQKLA 210 PVPSPEPQKP 220 APVSPESVKA 230 TLSNPKPQKQ 240 SHFPETLGPP 250 SASSPESPVL 260 AASPEPWGPS 270 PAASPESRKS 280 ARTTSPEPRK 290 PSPSESPEPW 300 KPFPAVSPEP 310 RRPAPAVSPG 320 SWKPGPPGSP 330 RPWKSNPSAS 340 SGPWKPAKPA 350 PSVSPGPWKP 360 IPSVSPGPWK 370 PTPSVSSASW 380 KSSSVSPSSW 390 KSPPASPESW 400 KSGPPELRKT 410 APTLSPEHWK 420 AVPPVSPELR 430 KPGPPLSPEI 440 RSPAGSPELR 450 KPSGSPDLWK 460 LSPDQRKTSP 470 ASLDFPESQK 480 SSRGGSPDLW 490 KSSFFIEPQK 500 PVFPETRKPG 510 PSGPSESPKA 520 ASDIWKPVLS 530 IDTEPRKPAL 540 FPEPAKTAPP 550 ASPEARKRAL 560 FPEPRKHALF 570 PELPKSALFS 580 ESQKAVELGD 590 ELQIDAIDDQ 600 KCDILVQEEL 610 LASPKKLLED 620 TLFPSSKKLK 630 KDNQESSDAE 640 LSSSEYIKTD 650 LDAMDIKGQE 660 SSSDQEQVDV 670 ESIDFSKENK 680 MDMTSPEQSR 690 NVLQFTEEKE 700 AFISEEEIAK 710 YMKRGKGKYY 720 CKICCCRAMK 730 KGAVLHHLVN 740 KHNVHSPYKC 750 TICGKAFLLE 760 SLLKNHVAAH 770 GQSLLKCPRC 780 NFESNFPRGF 790 KKHLTHCQSR 800 HNEEANKKLM 810 EALEPPLEEQ QI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000793 condensed chromosome
Biological Process GO:0034501 protein localization to kinetochore
Biological Process GO:0035372 protein localization to microtubule
Biological Process GO:0031134 sister chromatid biorientation
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051315 attachment of mitotic spindle microtubules to kinetochore

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.