Search Results
Overview
| Uniprot ID | Q96JM7 |
|---|---|
| Protein Name | Lethal(3)malignant brain tumor-like protein 3 |
| Gene Name | L3MBTL3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 168 | DNEEEDPKCSRKKKP |
Function
Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity)
Protein Sequence
10
MTESASSTSG
20
QEFDVFSVMD
30
WKDGVGTLPG
40
SDLKFRVNEF
50
GALEVITDEN
60
EMENVKKATA
70
TTTWMVPTAQ
80
EAPTSPPSSR
90
PVFPPAYWTS
100
PPGCPTVFSE
110
KTGMPFRLKD
120
PVKVEGLQFC
130
ENCCQYGNVD
140
ECLSGGNYCS
150
QNCARHIKDK
160
DQKEERDVEE
170
DNEEEDPKCS
180
RKKKPKLSLK
190
ADTKEDGEER
200
DDEMENKQDV
210
RILRGSQRAR
220
RKRRGDSAVL
230
KQGLPPKGKK
240
AWCWASYLEE
250
EKAVAVPAKL
260
FKEHQSFPYN
270
KNGFKVGMKL
280
EGVDPEHQSV
290
YCVLTVAEVC
300
GYRIKLHFDG
310
YSDCYDFWVN
320
ADALDIHPVG
330
WCEKTGHKLH
340
PPKGYKEEEF
350
NWQTYLKTCK
360
AQAAPKSLFE
370
NQNITVIPSG
380
FRVGMKLEAV
390
DKKNPSFICV
400
ATVTDMVDNR
410
FLVHFDNWDE
420
SYDYWCEASS
430
PHIHPVGWCK
440
EHRRTLITPP
450
GYPNVKHFSW
460
DKYLEETNSL
470
PAPARAFKVK
480
PPHGFQKKMK
490
LEVVDKRNPM
500
FIRVATVADT
510
DDHRVKVHFD
520
GWNNCYDYWI
530
DADSPDIHPV
540
GWCSKTGHPL
550
QPPLSPLELM
560
EASEHGGCST
570
PGCKGIGHFK
580
RARHLGPHSA
590
ANCPYSEINL
600
NKDRIFPDRL
610
SGEMPPASPS
620
FPRNKRTDAN
630
ESSSSPEIRD
640
QHADDVKEDF
650
EERTESEMRT
660
SHEARGAREE
670
PTVQQAQRRS
680
AVFLSFKSPI
690
PCLPLRWEQQ
700
SKLLPTVAGI
710
PASKVSKWST
720
DEVSEFIQSL
730
PGCEEHGKVF
740
KDEQIDGEAF
750
LLMTQTDIVK
760
IMSIKLGPAL
770
KIFNSILMFK
780
AAEKNSHNEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0140034 | methylation-dependent protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0160217 | negative regulation of transcription initiation-coupled chromatin remodeling |
| Biological Process | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
Reference
PMID: N/A