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Overview

Uniprot IDQ96JP5
Protein NameE3 ubiquitin-protein ligase ZFP91
Gene NameZFP91
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 SPSPVQGKKSPRLLC
109 PSPVQGKKSPRLLCI
174 NTRSSRSKTGSLQLI
382 EYCARAFKSSHNLAV

Function

DNA-binding transcription factor (PubMed:34936696, PubMed:40608935). Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK (PubMed:20682767). It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway (PubMed:20682767). May also play an important role in cell proliferation and/or anti-apoptosis (PubMed:12738986)

Protein Sequence

10 MPGETEEPRP 20 PEQQDQEGGE 30 AAKAAPEEPQ 40 QRPPEAVAAA 50 PAGTTSSRVL 60 RGGRDRGRAA 70 AAAAAAAVSR 80 RRKAEYPRRR 90 RSSPSARPPD 100 VPGQQPQAAK 110 SPSPVQGKKS 120 PRLLCIEKVT 130 TDKDPKEEKE 140 EEDDSALPQE 150 VSIAASRPSR 160 GWRSSRTSVS 170 RHRDTENTRS 180 SRSKTGSLQL 190 ICKSEPNTDQ 200 LDYDVGEEHQ 210 SPGGISSEEE 220 EEEEEEMLIS 230 EEEIPFKDDP 240 RDETYKPHLE 250 RETPKPRRKS 260 GKVKEEKEKK 270 EIKVEVEVEV 280 KEEENEIRED 290 EEPPRKRGRR 300 RKDDKSPRLP 310 KRRKKPPIQY 320 VRCEMEGCGT 330 VLAHPRYLQH 340 HIKYQHLLKK 350 KYVCPHPSCG 360 RLFRLQKQLL 370 RHAKHHTDQR 380 DYICEYCARA 390 FKSSHNLAVH 400 RMIHTGEKPL 410 QCEICGFTCR 420 QKASLNWHMK 430 KHDADSFYQF 440 SCNICGKKFE 450 KKDSVVAHKA 460 KSHPEVLIAE 470 ALAANAGALI 480 TSTDILGTNP 490 ESLTQPSDGQ 500 GLPLLPEPLG 510 NSTSGECLLL 520 EAEGMSKSYC 530 SGTERVSLMA 540 DGKIFVGSGS 550 SGGTEGLVMN 560 SDILGATTEV 570 LIEDSDSAGP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007250 activation of NF-kappaB-inducing kinase activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.