Search Results
Overview
| Uniprot ID | Q96JY6 |
|---|---|
| Protein Name | PDZ and LIM domain protein 2 |
| Gene Name | PDLIM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 282 | RALATPPKLHTCEKC |
Function
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity
Protein Sequence
10
MALTVDVAGP
20
APWGFRITGG
30
RDFHTPIMVT
40
KVAERGKAKD
50
ADLRPGDIIV
60
AINGESAEGM
70
LHAEAQSKIR
80
QSPSPLRLQL
90
DRSQATSPGQ
100
TNGDSSLEVL
110
ATRFQGSVRT
120
YTESQSSLRS
130
SYSSPTSLSP
140
RAGSPFSPPP
150
SSSSLTGEAA
160
ISRSFQSLAC
170
SPGLPAADRL
180
SYSGRPGSRQ
190
AGLGRAGDSA
200
VLVLPPSPGP
210
RSSRPSMDSE
220
GGSLLLDEDS
230
EVFKMLQENR
240
EGRAAPRQSS
250
SFRLLQEALE
260
AEERGGTPAF
270
LPSSLSPQSS
280
LPASRALATP
290
PKLHTCEKCS
300
TSIANQAVRI
310
QEGRYRHPGC
320
YTCADCGLNL
330
KMRGHFWVGD
340
ELYCEKHARQ
350
RYSAPATLSS
RA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051371 | muscle alpha-actinin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0030163 | protein catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.