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Overview

Uniprot ID	Q96K21
Protein Name	Abscission/NoCut checkpoint regulator
Gene Name	ZFYVE19
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
159	RVAALEAKQKPSTSQ

Function

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission

Protein Sequence

10 MNYDSQQPPL 20 PPLPYAGCRR 30 ASGFPALGRG 40 GTVPVGVWGG 50 AGQGREGRSW 60 GEGPRGPGLG 70 RRDLSSADPA 80 VLGATMESRC 90 YGCAVKFTLF 100 KKEYGCKNCG 110 RAFCSGCLSF 120 SAAVPRTGNT 130 QQKVCKQCHE 140 VLTRGSSANA 150 SKWSPPQNYK 160 KRVAALEAKQ 170 KPSTSQSQGL 180 TRQDQMIAER 190 LARLRQENKP 200 KLVPSQAEIE 210 ARLAALKDER 220 QGSIPSTQEM 230 EARLAALQGR 240 VLPSQTPQPA 250 HHTPDTRTQA 260 QQTQDLLTQL 270 AAEVAIDESW 280 KGGGPAASLQ 290 NDLNQGGPGS 300 TNSKRQANWS 310 LEEEKSRLLA 320 EAALELREEN 330 TRQERILALA 340 KRLAMLRGQD 350 PERVTLQDYR 360 LPDSDDDEDE 370 ETAIQRVLQQ 380 LTEEASLDEA 390 SGFNIPAEQA 400 SRPWTQPRGA 410 EPEAQDVDPR 420 PEAEEEELPW 430 CCICNEDATL 440 RCAGCDGDLF 450 CARCFREGHD 460 AFELKEHQTS 470 AYSPPRAGQE H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0032154	cleavage furrow
Cellular Component	GO:0090543	Flemming body
Cellular Component	GO:0030496	midbody
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0061952	midbody abscission
Biological Process	GO:0044878	mitotic cytokinesis checkpoint signaling
Biological Process	GO:0032466	negative regulation of cytokinesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.