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Overview

Uniprot IDQ96K76
Protein NameUbiquitin carboxyl-terminal hydrolase 47
Gene NameUSP47
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
121 DANFEPGKKNFLHLT
1361 PRKEKALKIYLDGAP
54 IQDTTNSKTVNERIT
838 QSPVSYSKRTAYQKA

Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level

Protein Sequence

10 MVPGEENQLV 20 PKEDVFWRCR 30 QNIFDEMKKK 40 FLQIENAAEE 50 PRVLCIIQDT 60 TNSKTVNERI 70 TLNLPASTPV 80 RKLFEDVANK 90 VGYINGTFDL 100 VWGNGINTAD 110 MAPLDHTSDK 120 SLLDANFEPG 130 KKNFLHLTDK 140 DGEQPQILLE 150 DSSAGEDSVH 160 DRFIGPLPRE 170 GSGGSTSDYV 180 SQSYSYSSIL 190 NKSETGYVGL 200 VNQAMTCYLN 210 SLLQTLFMTP 220 EFRNALYKWE 230 FEESEEDPVT 240 SIPYQLQRLF 250 VLLQTSKKRA 260 IETTDVTRSF 270 GWDSSEAWQQ 280 HDVQELCRVM 290 FDALEQKWKQ 300 TEQADLINEL 310 YQGKLKDYVR 320 CLECGYEGWR 330 IDTYLDIPLV 340 IRPYGSSQAF 350 ASVEEALHAF 360 IQPEILDGPN 370 QYFCERCKKK 380 CDARKGLRFL 390 HFPYLLTLQL 400 KRFDFDYTTM 410 HRIKLNDRMT 420 FPEELDMSTF 430 IDVEDEKSPQ 440 TESCTDSGAE 450 NEGSCHSDQM 460 SNDFSNDDGV 470 DEGICLETNS 480 GTEKISKSGL 490 EKNSLIYELF 500 SVMVHSGSAA 510 GGHYYACIKS 520 FSDEQWYSFN 530 DQHVSRITQE 540 DIKKTHGGSS 550 GSRGYYSSAF 560 ASSTNAYMLI 570 YRLKDPARNA 580 KFLEVDEYPE 590 HIKNLVQKER 600 ELEEQEKRQR 610 EIERNTCKIK 620 LFCLHPTKQV 630 MMENKLEVHK 640 DKTLKEAVEM 650 AYKMMDLEEV 660 IPLDCCRLVK 670 YDEFHDYLER 680 SYEGEEDTPM 690 GLLLGGVKST 700 YMFDLLLETR 710 KPDQVFQSYK 720 PGEVMVKVHV 730 VDLKAESVAA 740 PITVRAYLNQ 750 TVTEFKQLIS 760 KAIHLPAETM 770 RIVLERCYND 780 LRLLSVSSKT 790 LKAEGFFRSN 800 KVFVESSETL 810 DYQMAFADSH 820 LWKLLDRHAN 830 TIRLFVLLPE 840 QSPVSYSKRT 850 AYQKAGGDSG 860 NVDDDCERVK 870 GPVGSLKSVE 880 AILEESTEKL 890 KSLSLQQQQD 900 GDNGDSSKST 910 ETSDFENIES 920 PLNERDSSAS 930 VDNRELEQHI 940 QTSDPENFQS 950 EERSDSDVNN 960 DRSTSSVDSD 970 ILSSSHSSDT 980 LCNADNAQIP 990 LANGLDSHSI 1000 TSSRRTKANE 1010 GKKETWDTAE 1020 EDSGTDSEYD 1030 ESGKSRGEMQ 1040 YMYFKAEPYA 1050 ADEGSGEGHK 1060 WLMVHVDKRI 1070 TLAAFKQHLE 1080 PFVGVLSSHF 1090 KVFRVYASNQ 1100 EFESVRLNET 1110 LSSFSDDNKI 1120 TIRLGRALKK 1130 GEYRVKVYQL 1140 LVNEQEPCKF 1150 LLDAVFAKGM 1160 TVRQSKEELI 1170 PQLREQCGLE 1180 LSIDRFRLRK 1190 KTWKNPGTVF 1200 LDYHIYEEDI 1210 NISSNWEVFL 1220 EVLDGVEKMK 1230 SMSQLAVLSR 1240 RWKPSEMKLD 1250 PFQEVVLESS 1260 SVDELREKLS 1270 EISGIPLDDI 1280 EFAKGRGTFP 1290 CDISVLDIHQ 1300 DLDWNPKVST 1310 LNVWPLYICD 1320 DGAVIFYRDK 1330 TEELMELTDE 1340 QRNELMKKES 1350 SRLQKTGHRV 1360 TYSPRKEKAL 1370 KIYLDGAPNK DLTQD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0019005 SCF ubiquitin ligase complex
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0101005 deubiquitinase activity
Molecular Function GO:0071987 WD40-repeat domain binding
Biological Process GO:0006284 base-excision repair
Biological Process GO:0006974 DNA damage response
Biological Process GO:0035520 monoubiquitinated protein deubiquitination
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0031647 regulation of protein stability

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.