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Overview

Uniprot ID	Q96KB5
Protein Name	Lymphokine-activated killer T-cell-originated protein kinase
Gene Name	PBK
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
12	SNFKTPSKLSEKKKS
18	SKLSEKKKSVLCSTP
65	HSPWAVKKINPICND
8	MEGISNFKTPSKLSE

Function

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage

Protein Sequence

10 MEGISNFKTP 20 SKLSEKKKSV 30 LCSTPTINIP 40 ASPFMQKLGF 50 GTGVNVYLMK 60 RSPRGLSHSP 70 WAVKKINPIC 80 NDHYRSVYQK 90 RLMDEAKILK 100 SLHHPNIVGY 110 RAFTEANDGS 120 LCLAMEYGGE 130 KSLNDLIEER 140 YKASQDPFPA 150 AIILKVALNM 160 ARGLKYLHQE 170 KKLLHGDIKS 180 SNVVIKGDFE 190 TIKICDVGVS 200 LPLDENMTVT 210 DPEACYIGTE 220 PWKPKEAVEE 230 NGVITDKADI 240 FAFGLTLWEM 250 MTLSIPHINL 260 SNDDDDEDKT 270 FDESDFDDEA 280 YYAALGTRPP 290 INMEELDESY 300 QKVIELFSVC 310 TNEDPKDRPS 320 AAHIVEALET DV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004708	MAP kinase kinase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0004713	protein tyrosine kinase activity
Biological Process	GO:0000278	mitotic cell cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.