Search Results

Overview

Uniprot IDQ96KG9
Protein NameN-terminal kinase-like protein
Gene NameSCYL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
771 ETDSRQVKAELARKK
801 KVAKGPMKLGARKLD

Function

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903)

Protein Sequence

10 MWFFARDPVR 20 DFPFELIPEP 30 PEGGLPGPWA 40 LHRGRKKATG 50 SPVSIFVYDV 60 KPGAEEQTQV 70 AKAAFKRFKT 80 LRHPNILAYI 90 DGLETEKCLH 100 VVTEAVTPLG 110 IYLKARVEAG 120 GLKELEISWG 130 LHQIVKALSF 140 LVNDCSLIHN 150 NVCMAAVFVD 160 RAGEWKLGGL 170 DYMYSAQGNG 180 GGPPRKGIPE 190 LEQYDPPELA 200 DSSGRVVREK 210 WSADMWRLGC 220 LIWEVFNGPL 230 PRAAALRNPG 240 KIPKTLVPHY 250 CELVGANPKV 260 RPNPARFLQN 270 CRAPGGFMSN 280 RFVETNLFLE 290 EIQIKEPAEK 300 QKFFQELSKS 310 LDAFPEDFCR 320 HKVLPQLLTA 330 FEFGNAGAVV 340 LTPLFKVGKF 350 LSAEEYQQKI 360 IPVVVKMFSS 370 TDRAMRIRLL 380 QQMEQFIQYL 390 DEPTVNTQIF 400 PHVVHGFLDT 410 NPAIREQTVK 420 SMLLLAPKLN 430 EANLNVELMK 440 HFARLQAKDE 450 QGPIRCNTTV 460 CLGKIGSYLS 470 ASTRHRVLTS 480 AFSRATRDPF 490 APSRVAGVLG 500 FAATHNLYSM 510 NDCAQKILPV 520 LCGLTVDPEK 530 SVRDQAFKAI 540 RSFLSKLESV 550 SEDPTQLEEV 560 EKDVHAASSP 570 GMGGAAASWA 580 GWAVTGVSSL 590 TSKLIRSHPT 600 TAPTETNIPQ 610 RPTPEGVPAP 620 APTPVPATPT 630 TSGHWETQEE 640 DKDTAEDSST 650 ADRWDDEDWG 660 SLEQEAESVL 670 AQQDDWSTGG 680 QVSRASQVSN 690 SDHKSSKSPE 700 SDWSSWEAEG 710 SWEQGWQEPS 720 SQEPPPDGTR 730 LASEYNWGGP 740 ESSDKGDPFA 750 TLSARPSTQP 760 RPDSWGEDNW 770 EGLETDSRQV 780 KAELARKKRE 790 ERRREMEAKR 800 AERKVAKGPM KLGARKLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005801 cis-Golgi network
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0004672 protein kinase activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.