Search Results

Overview

Uniprot IDQ96KM6
Protein NameZinc finger protein 512B
Gene NameZNF512B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
17 RRLPGSSKSGPGKDG
190 SRPVGVSKPIGVSKP
202 SKPVTIGKPVGVSKP
208 GKPVGVSKPIGISKP
226 GRPMPVTKAIPVTRP
238 TRPVPVTKPVTVSRP
274 TKPVPVTKPITVTKL
304 SRPIVVSKPVTVSRP
322 SRHTPPCKMVLLTRS
429 RKQKTPKKFTGEQPS
459 KARVHRSKKQEGPGP
460 ARVHRSKKQEGPGPE
472 GPEDARKKVPAAPIT

Function

Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiate heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation (By similarity)

Protein Sequence

10 MTDPFCVGGR 20 RLPGSSKSGP 30 GKDGSRKEVR 40 LPMLHDPPKM 50 GMPVVRGGQT 60 VPGQAPLCFD 70 PGSPASDKTE 80 GKKKGRPKAE 90 NQALRDIPLS 100 LMNDWKDEFK 110 AHSRVKCPNS 120 GCWLEFPSIY 130 GLKYHYQRCQ 140 GGAISDRLAF 150 PCPFCEAAFT 160 SKTQLEKHRI 170 WNHMDRPLPA 180 SKPGPISRPV 190 TISRPVGVSK 200 PIGVSKPVTI 210 GKPVGVSKPI 220 GISKPVSVGR 230 PMPVTKAIPV 240 TRPVPVTKPV 250 TVSRPMPVTK 260 AMPVTKPITV 270 TKSVPVTKPV 280 PVTKPITVTK 290 LVTVTKPVPV 300 TKPVTVSRPI 310 VVSKPVTVSR 320 PIAISRHTPP 330 CKMVLLTRSE 340 NKAPRATGRN 350 SGKKRAADSL 360 DTCPIPPKQA 370 RPENGEYGPS 380 SMGQSSAFQL 390 SADTSSGSLS 400 PGSRPSGGME 410 ALKAAGPASP 420 PEEDPERTKH 430 RRKQKTPKKF 440 TGEQPSISGT 450 FGLKGLVKAE 460 DKARVHRSKK 470 QEGPGPEDAR 480 KKVPAAPITV 490 SKEAPAPVAH 500 PAPGGPEEQW 510 QRAIHERGEA 520 VCPTCNVVTR 530 KTLVGLKKHM 540 EVCQKLQDAL 550 KCQHCRKQFK 560 SKAGLNYHTM 570 AEHSAKPSDA 580 EASEGGEQEE 590 RERLRKVLKQ 600 MGRLRCPQEG 610 CGAAFSSLMG 620 YQYHQRRCGK 630 PPCEVDSPSF 640 PCTHCGKTYR 650 SKAGHDYHVR 660 SEHTAPPPEE 670 PTDKSPEAED 680 PLGVERTPSG 690 RVRRTSAQVA 700 VFHLQEIAED 710 ELARDWTKRR 720 MKDDLVPETA 730 RLNYTRPGLP 740 TLNPQLLEAW 750 KNEVKEKGHV 760 NCPNDCCEAI 770 YSSVSGLKAH 780 LASCSKGAHL 790 AGKYRCLLCP 800 KEFSSESGVK 810 YHILKTHAEN 820 WFRTSADPPP 830 KHRSQDSLVP 840 KKEKKKNLAG 850 GKKRGRKPKE 860 RTPEEPVAKL 870 PPRRDDWPPG 880 CRDKGARGST 890 GRKVGVSKAP EK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0140719 constitutive heterochromatin formation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1902894 negative regulation of miRNA transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.