Search Results
Overview
| Uniprot ID | Q96KP6 |
|---|---|
| Protein Name | TNFAIP3-interacting protein 3 |
| Gene Name | TNIP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | HELKEENKLLKGKNT |
| 142 | KEENKLLKGKNTLAN |
Function
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding
Protein Sequence
10
MAHFVQGTSR
20
MIAAESSTEH
30
KECAEPSTRK
40
NLMNSLEQKI
50
RCLEKQRKEL
60
LEVNQQWDQQ
70
FRSMKELYER
80
KVAELKTKLD
90
AAERFLSTRE
100
KDPHQRQRKD
110
DRQREDDRQR
120
DLTRDRLQRE
130
EKEKERLNEE
140
LHELKEENKL
150
LKGKNTLANK
160
EKEHYECEIK
170
RLNKALQDAL
180
NIKCSFSEDC
190
LRKSRVEFCH
200
EEMRTEMEVL
210
KQQVQIYEED
220
FKKERSDRER
230
LNQEKEELQQ
240
INETSQSQLN
250
RLNSQIKACQ
260
MEKEKLEKQL
270
KQMYCPPCNC
280
GLVFHLQDPW
290
VPTGPGAVQK
300
QREHPPDYQW
310
YALDQLPPDV
320
QHKANGLSSV
KKVHP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0031593 | polyubiquitin modification-dependent protein binding |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034142 | toll-like receptor 4 signaling pathway |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.