Search Results

Overview

Uniprot IDQ96KR1
Protein NameZinc finger RNA-binding protein
Gene NameZFR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
310 WTGTTFTKKAPFQNK
311 TGTTFTKKAPFQNKQ
317 KKAPFQNKQLKPKQP
354 KEHLEGQKHKKKEAA
356 HLEGQKHKKKEAALK
415 KVVKLHTKLGKPIPS
495 VPTNMAAKKTSTPKI
496 PTNMAAKKTSTPKIN
501 AKKTSTPKINFVGGN
509 INFVGGNKLQSTGNK
527 IKGTECVKSTPVTSA
888 DVTSGMVKDPPDVLD

Function

Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity)

Protein Sequence

10 MIPICPVVSF 20 TYVPSRLGED 30 AKMATGNYFG 40 FTHSGAAAAA 50 AAAQYSQQPA 60 SGVAYSHPTT 70 VASYTVHQAP 80 VAAHTVTAAY 90 APAAATVAVA 100 RPAPVAVAAA 110 ATAAAYGGYP 120 TAHTATDYGY 130 TQRQQEAPPP 140 PPPATTQNYQ 150 DSYSYVRSTA 160 PAVAYDSKQY 170 YQQPTATAAA 180 VAAAAQPQPS 190 VAETYYQTAP 200 KAGYSQGATQ 210 YTQAQQTRQV 220 TAIKPATPSP 230 ATTTFSIYPV 240 SSTVQPVAAA 250 ATVVPSYTQS 260 ATYSTTAVTY 270 SGTSYSGYEA 280 AVYSAASSYY 290 QQQQQQQKQA 300 AAAAAAAAAT 310 AAWTGTTFTK 320 KAPFQNKQLK 330 PKQPPKPPQI 340 HYCDVCKISC 350 AGPQTYKEHL 360 EGQKHKKKEA 370 ALKASQNTSS 380 SNSSTRGTQN 390 QLRCELCDVS 400 CTGADAYAAH 410 IRGAKHQKVV 420 KLHTKLGKPI 430 PSTEPNVVSQ 440 ATSSTAVSAS 450 KPTASPSSIA 460 ANNCTVNTSS 470 VATSSMKGLT 480 TTGNSSLNST 490 SNTKVSAVPT 500 NMAAKKTSTP 510 KINFVGGNKL 520 QSTGNKAEDI 530 KGTECVKSTP 540 VTSAVQIPEV 550 KQDTVSEPVT 560 PASLAALQSD 570 VQPVGHDYVE 580 EVRNDEGKVI 590 RFHCKLCECS 600 FNDPNAKEMH 610 LKGRRHRLQY 620 KKKVNPDLQV 630 EVKPSIRARK 640 IQEEKMRKQM 650 QKEEYWRRRE 660 EEERWRMEMR 670 RYEEDMYWRR 680 MEEEQHHWDD 690 RRRMPDGGYP 700 HGPPGPLGLL 710 GVRPGMPPQP 720 QGPAPLRRPD 730 SSDDRYVMTK 740 HATIYPTEEE 750 LQAVQKIVSI 760 TERALKLVSD 770 SLSEHEKNKN 780 KEGDDKKEGG 790 KDRALKGVLR 800 VGVLAKGLLL 810 RGDRNVNLVL 820 LCSEKPSKTL 830 LSRIAENLPK 840 QLAVISPEKY 850 DIKCAVSEAA 860 IILNSCVEPK 870 MQVTITLTSP 880 IIREENMREG 890 DVTSGMVKDP 900 PDVLDRQKCL 910 DALAALRHAK 920 WFQARANGLQ 930 SCVIIIRILR 940 DLCQRVPTWS 950 DFPSWAMELL 960 VEKAISSASS 970 PQSPGDALRR 980 VFECISSGII 990 LKGSPGLLDP 1000 CEKDPFDTLA 1010 TMTDQQREDI 1020 TSSAQFALRL 1030 LAFRQIHKVL 1040 GMDPLPQMSQ 1050 RFNIHNNRKR 1060 RRDSDGVDGF 1070 EAEGKKDKKD YDNF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003727 single-stranded RNA binding
Molecular Function GO:0008270 zinc ion binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.