Search Results

Overview

Uniprot IDQ96L73
Protein NameHistone-lysine N-methyltransferase, H3 lysine-36 specific
Gene NameNSD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2506 HMPRAVEKGCVSDPL
2578 SQSPGLVKQAKQMVG
2581 PGLVKQAKQMVGGQQ
2605 QSFRSLGKAPASLPT
781 NQALLHSKSKQPKFR

Function

Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context

Protein Sequence

10 MDQTCELPRR 20 NCLLPFSNPV 30 NLDAPEDKDS 40 PFGNGQSNFS 50 EPLNGCTMQL 60 STVSGTSQNA 70 YGQDSPSCYI 80 PLRRLQDLAS 90 MINVEYLNGS 100 ADGSESFQDP 110 EKSDSRAQTP 120 IVCTSLSPGG 130 PTALAMKQEP 140 SCNNSPELQV 150 KVTKTIKNGF 160 LHFENFTCVD 170 DADVDSEMDP 180 EQPVTEDESI 190 EEIFEETQTN 200 ATCNYETKSE 210 NGVKVAMGSE 220 QDSTPESRHG 230 AVKSPFLPLA 240 PQTETQKNKQ 250 RNEVDGSNEK 260 AALLPAPFSL 270 GDTNITIEEQ 280 LNSINLSFQD 290 DPDSSTSTLG 300 NMLELPGTSS 310 SSTSQELPFC 320 QPKKKSTPLK 330 YEVGDLIWAK 340 FKRRPWWPCR 350 ICSDPLINTH 360 SKMKVSNRRP 370 YRQYYVEAFG 380 DPSERAWVAG 390 KAIVMFEGRH 400 QFEELPVLRR 410 RGKQKEKGYR 420 HKVPQKILSK 430 WEASVGLAEQ 440 YDVPKGSKNR 450 KCIPGSIKLD 460 SEEDMPFEDC 470 TNDPESEHDL 480 LLNGCLKSLA 490 FDSEHSADEK 500 EKPCAKSRAR 510 KSSDNPKRTS 520 VKKGHIQFEA 530 HKDERRGKIP 540 ENLGLNFISG 550 DISDTQASNE 560 LSRIANSLTG 570 SNTAPGSFLF 580 SSCGKNTAKK 590 EFETSNGDSL 600 LGLPEGALIS 610 KCSREKNKPQ 620 RSLVCGSKVK 630 LCYIGAGDEE 640 KRSDSISICT 650 TSDDGSSDLD 660 PIEHSSESDN 670 SVLEIPDAFD 680 RTENMLSMQK 690 NEKIKYSRFA 700 ATNTRVKAKQ 710 KPLISNSHTD 720 HLMGCTKSAE 730 PGTETSQVNL 740 SDLKASTLVH 750 KPQSDFTNDA 760 LSPKFNLSSS 770 ISSENSLIKG 780 GAANQALLHS 790 KSKQPKFRSI 800 KCKHKENPVM 810 AEPPVINEEC 820 SLKCCSSDTK 830 GSPLASISKS 840 GKVDGLKLLN 850 NMHEKTRDSS 860 DIETAVVKHV 870 LSELKELSYR 880 SLGEDVSDSG 890 TSKPSKPLLF 900 SSASSQNHIP 910 IEPDYKFSTL 920 LMMLKDMHDS 930 KTKEQRLMTA 940 QNLVSYRSPG 950 RGDCSTNSPV 960 GVSKVLVSGG 970 STHNSEKKGD 980 GTQNSANPSP 990 SGGDSALSGE 1000 LSASLPGLLS 1010 DKRDLPASGK 1020 SRSDCVTRRN 1030 CGRSKPSSKL 1040 RDAFSAQMVK 1050 NTVNRKALKT 1060 ERKRKLNQLP 1070 SVTLDAVLQG 1080 DRERGGSLRG 1090 GAEDPSKEDP 1100 LQIMGHLTSE 1110 DGDHFSDVHF 1120 DSKVKQSDPG 1130 KISEKGLSFE 1140 NGKGPELDSV 1150 MNSENDELNG 1160 VNQVVPKKRW 1170 QRLNQRRTKP 1180 RKRMNRFKEK 1190 ENSECAFRVL 1200 LPSDPVQEGR 1210 DEFPEHRTPS 1220 ASILEEPLTE 1230 QNHADCLDSA 1240 GPRLNVCDKS 1250 SASIGDMEKE 1260 PGIPSLTPQA 1270 ELPEPAVRSE 1280 KKRLRKPSKW 1290 LLEYTEEYDQ 1300 IFAPKKKQKK 1310 VQEQVHKVSS 1320 RCEEESLLAR 1330 GRSSAQNKQV 1340 DENSLISTKE 1350 EPPVLEREAP 1360 FLEGPLAQSE 1370 LGGGHAELPQ 1380 LTLSVPVAPE 1390 VSPRPALESE 1400 ELLVKTPGNY 1410 ESKRQRKPTK 1420 KLLESNDLDP 1430 GFMPKKGDLG 1440 LSKKCYEAGH 1450 LENGITESCA 1460 TSYSKDFGGG 1470 TTKIFDKPRK 1480 RKRQRHAAAK 1490 MQCKKVKNDD 1500 SSKEIPGSEG 1510 ELMPHRTATS 1520 PKETVEEGVE 1530 HDPGMPASKK 1540 MQGERGGGAA 1550 LKENVCQNCE 1560 KLGELLLCEA 1570 QCCGAFHLEC 1580 LGLTEMPRGK 1590 FICNECRTGI 1600 HTCFVCKQSG 1610 EDVKRCLLPL 1620 CGKFYHEECV 1630 QKYPPTVMQN 1640 KGFRCSLHIC 1650 ITCHAANPAN 1660 VSASKGRLMR 1670 CVRCPVAYHA 1680 NDFCLAAGSK 1690 ILASNSIICP 1700 NHFTPRRGCR 1710 NHEHVNVSWC 1720 FVCSEGGSLL 1730 CCDSCPAAFH 1740 RECLNIDIPE 1750 GNWYCNDCKA 1760 GKKPHYREIV 1770 WVKVGRYRWW 1780 PAEICHPRAV 1790 PSNIDKMRHD 1800 VGEFPVLFFG 1810 SNDYLWTHQA 1820 RVFPYMEGDV 1830 SSKDKMGKGV 1840 DGTYKKALQE 1850 AAARFEELKA 1860 QKELRQLQED 1870 RKNDKKPPPY 1880 KHIKVNRPIG 1890 RVQIFTADLS 1900 EIPRCNCKAT 1910 DENPCGIDSE 1920 CINRMLLYEC 1930 HPTVCPAGGR 1940 CQNQCFSKRQ 1950 YPEVEIFRTL 1960 QRGWGLRTKT 1970 DIKKGEFVNE 1980 YVGELIDEEE 1990 CRARIRYAQE 2000 HDITNFYMLT 2010 LDKDRIIDAG 2020 PKGNYARFMN 2030 HCCQPNCETQ 2040 KWSVNGDTRV 2050 GLFALSDIKA 2060 GTELTFNYNL 2070 ECLGNGKTVC 2080 KCGAPNCSGF 2090 LGVRPKNQPI 2100 ATEEKSKKFK 2110 KKQQGKRRTQ 2120 GEITKEREDE 2130 CFSCGDAGQL 2140 VSCKKPGCPK 2150 VYHADCLNLT 2160 KRPAGKWECP 2170 WHQCDICGKE 2180 AASFCEMCPS 2190 SFCKQHREGM 2200 LFISKLDGRL 2210 SCTEHDPCGP 2220 NPLEPGEIRE 2230 YVPPPVPLPP 2240 GPSTHLAEQS 2250 TGMAAQAPKM 2260 SDKPPADTNQ 2270 MLSLSKKALA 2280 GTCQRPLLPE 2290 RPLERTDSRP 2300 QPLDKVRDLA 2310 GSGTKSQSLV 2320 SSQRPLDRPP 2330 AVAGPRPQLS 2340 DKPSPVTSPS 2350 SSPSVRSQPL 2360 ERPLGTADPR 2370 LDKSIGAASP 2380 RPQSLEKTSV 2390 PTGLRLPPPD 2400 RLLITSSPKP 2410 QTSDRPTDKP 2420 HASLSQRLPP 2430 PEKVLSAVVQ 2440 TLVAKEKALR 2450 PVDQNTQSKN 2460 RAALVMDLID 2470 LTPRQKERAA 2480 SPHQVTPQAD 2490 EKMPVLESSS 2500 WPASKGLGHM 2510 PRAVEKGCVS 2520 DPLQTSGKAA 2530 APSEDPWQAV 2540 KSLTQARLLS 2550 QPPAKAFLYE 2560 PTTQASGRAS 2570 AGAEQTPGPL 2580 SQSPGLVKQA 2590 KQMVGGQQLP 2600 ALAAKSGQSF 2610 RSLGKAPASL 2620 PTEEKKLVTT 2630 EQSPWALGKA 2640 SSRAGLWPIV 2650 AGQTLAQSCW 2660 SAGSTQTLAQ 2670 TCWSLGRGQD 2680 PKPEQNTLPA 2690 LNQAPSSHKC AESEQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140938 histone H3 methyltransferase activity
Molecular Function GO:0140954 histone H3K36 dimethyltransferase activity
Molecular Function GO:0046975 histone H3K36 methyltransferase activity
Molecular Function GO:0042799 histone H4K20 methyltransferase activity
Molecular Function GO:0050681 nuclear androgen receptor binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0042974 nuclear retinoic acid receptor binding
Molecular Function GO:0046965 nuclear retinoid X receptor binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032259 methylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0033135 regulation of peptidyl-serine phosphorylation
Biological Process GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Reference

PMID: N/A