Search Results

Overview

Uniprot ID	Q96L91
Protein Name	E1A-binding protein p400
Gene Name	EP400
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1553	ASPAHPAKLRAQTTA
2327	RATPGLLKIRREGKE
2811	AQIKAVGKLTPEHLI
2819	LTPEHLIKMQKQKLQ
2970	MQQLLKLKQQAVQQQ
908	KKALNLQKVSRRGKE

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Protein Sequence

10 MHHGTGPQNV 20 QHQLQRSRAC 30 PGSEGEEQPA 40 HPNPPPSPAA 50 PFAPSASPSA 60 PQSPSYQIQQ 70 LMNRSPATGQ 80 NVNITLQSVG 90 PVVGGNQQIT 100 LAPLPLPSPT 110 SPGFQFSAQP 120 RRFEHGSPSY 130 IQVTSPLSQQ 140 VQTQSPTQPS 150 PGPGQALQNV 160 RAGAPGPGLG 170 LCSSSPTGGF 180 VDASVLVRQI 190 SLSPSSGGHF 200 VFQDGSGLTQ 210 IAQGAQVQLQ 220 HPGTPITVRE 230 RRPSQPHTQS 240 GGTIHHLGPQ 250 SPAAAGGAGL 260 QPLASPSHIT 270 TANLPPQISS 280 IIQGQLVQQQ 290 QVLQGPPLPR 300 PLGFERTPGV 310 LLPGAGGAAG 320 FGMTSPPPPT 330 SPSRTAVPPG 340 LSSLPLTSVG 350 NTGMKKVPKK 360 LEEIPPASPE 370 MAQMRKQCLD 380 YHYQEMQALK 390 EVFKEYLIEL 400 FFLQHFQGNM 410 MDFLAFKKKH 420 YAPLQAYLRQ 430 NDLDIEEEEE 440 EEEEEEEKSE 450 VINDEVKVVT 460 GKDGQTGTPV 470 AIATQLPPKV 480 SAAFSSQQQP 490 FQQALAGSLV 500 AGAGSTVETD 510 LFKRQQAMPS 520 TGMAEQSKRP 530 RLEVGHQGVV 540 FQHPGADAGV 550 PLQQLMPTAQ 560 GGMPPTPQAA 570 QLAGQRQSQQ 580 QYDPSTGPPV 590 QNAASLHTPL 600 PQLPGRLPPA 610 GVPTAALSSA 620 LQFAQQPQVV 630 EAQTQLQIPV 640 KTQQPNVPIP 650 APPSSQLPIP 660 PSQPAQLALH 670 VPTPGKVQVQ 680 ASQLSSLPQM 690 VASTRLPVDP 700 APPCPRPLPT 710 SSTSSLAPVS 720 GSGPGPSPAR 730 SSPVNRPSSA 740 TNKALSPVTS 750 RTPGVVASAP 760 TKPQSPAQNA 770 TSSQDSSQDT 780 LTEQITLENQ 790 VHQRIAELRK 800 AGLWSQRRLP 810 KLQEAPRPKS 820 HWDYLLEEMQ 830 WMATDFAQER 840 RWKVAAAKKL 850 VRTVVRHHEE 860 KQLREERGKK 870 EEQSRLRRIA 880 ASTAREIECF 890 WSNIEQVVEI 900 KLRVELEEKR 910 KKALNLQKVS 920 RRGKELRPKG 930 FDALQESSLD 940 SGMSGRKRKA 950 SISLTDDEVD 960 DEEETIEEEE 970 ANEGVVDHQT 980 ELSNLAKEAE 990 LPLLDLMKLY 1000 EGAFLPSSQW 1010 PRPKPDGEDT 1020 SGEEDADDCP 1030 GDRESRKDLV 1040 LIDSLFIMDQ 1050 FKAAERMNIG 1060 KPNAKDIADV 1070 TAVAEAILPK 1080 GSARVTTSVK 1090 FNAPSLLYGA 1100 LRDYQKIGLD 1110 WLAKLYRKNL 1120 NGILADEAGL 1130 GKTVQIIAFF 1140 AHLACNEGNW 1150 GPHLVVVRSC 1160 NILKWELELK 1170 RWCPGLKILS 1180 YIGSHRELKA 1190 KRQEWAEPNS 1200 FHVCITSYTQ 1210 FFRGLTAFTR 1220 VRWKCLVIDE 1230 MQRVKGMTER 1240 HWEAVFTLQS 1250 QQRLLLIDSP 1260 LHNTFLELWT 1270 MVHFLVPGIS 1280 RPYLSSPLRA 1290 PSEESQDYYH 1300 KVVIRLHRVT 1310 QPFILRRTKR 1320 DVEKQLTKKY 1330 EHVLKCRLSN 1340 RQKALYEDVI 1350 LQPGTQEALK 1360 SGHFVNVLSI 1370 LVRLQRICNH 1380 PGLVEPRHPG 1390 SSYVAGPLEY 1400 PSASLILKAL 1410 ERDFWKEADL 1420 SMFDLIGLEN 1430 KITRHEAELL 1440 SKKKIPRKLM 1450 EEISTSAAPA 1460 ARPAAAKLKA 1470 SRLFQPVQYG 1480 QKPEGRTVAF 1490 PSTHPPRTAA 1500 PTTASAAPQG 1510 PLRGRPPIAT 1520 FSANPEAKAA 1530 AAPFQTSQAS 1540 ASAPRHQPAS 1550 ASSTAASPAH 1560 PAKLRAQTTA 1570 QASTPGQPPP 1580 QPQAPSHAAG 1590 QSALPQRLVL 1600 PSQAQARLPS 1610 GEVVKIAQLA 1620 SITGPQSRVA 1630 QPETPVTLQF 1640 QGSKFTLSHS 1650 QLRQLTAGQP 1660 LQLQGSVLQI 1670 VSAPGQPYLR 1680 APGPVVMQTV 1690 SQAGAVHGAL 1700 GSKPPAGGPS 1710 PAPLTPQVGV 1720 PGRVAVNALA 1730 VGEPGTASKP 1740 ASPIGGPTQE 1750 EKTRLLKERL 1760 DQIYLVNERR 1770 CSQAPVYGRD 1780 LLRICALPSH 1790 GRVQWRGSLD 1800 GRRGKEAGPA 1810 HSYTSSSESP 1820 SELMLTLCRC 1830 GESLQDVIDR 1840 VAFVIPPVVA 1850 APPSLRVPRP 1860 PPLYSHRMRI 1870 LRQGLREHAA 1880 PYFQQLRQTT 1890 APRLLQFPEL 1900 RLVQFDSGKL 1910 EALAILLQKL 1920 KSEGRRVLIL 1930 SQMILMLDIL 1940 EMFLNFHYLT 1950 YVRIDENASS 1960 EQRQELMRSF 1970 NRDRRIFCAI 1980 LSTHSRTTGI 1990 NLVEADTVVF 2000 YDNDLNPVMD 2010 AKAQEWCDRI 2020 GRCKDIHIYR 2030 LVSGNSIEEK 2040 LLKNGTKDLI 2050 REVAAQGNDY 2060 SMAFLTQRTI 2070 QELFEVYSPM 2080 DDAGFPVKAE 2090 EFVVLSQEPS 2100 VTETIAPKIA 2110 RPFIEALKSI 2120 EYLEEDAQKS 2130 AQEGVLGPHT 2140 DALSSDSENM 2150 PCDEEPSQLE 2160 ELADFMEQLT 2170 PIEKYALNYL 2180 ELFHTSIEQE 2190 KERNSEDAVM 2200 TAVRAWEFWN 2210 LKTLQEREAR 2220 LRLEQEEAEL 2230 LTYTREDAYS 2240 MEYVYEDVDG 2250 QTEVMPLWTP 2260 PTPPQDDSDI 2270 YLDSVMCLMY 2280 EATPIPEAKL 2290 PPVYVRKERK 2300 RHKTDPSAAG 2310 RKKKQRHGEA 2320 VVPPRSLFDR 2330 ATPGLLKIRR 2340 EGKEQKKNIL 2350 LKQQVPFAKP 2360 LPTFAKPTAE 2370 PGQDNPEWLI 2380 SEDWALLQAV 2390 KQLLELPLNL 2400 TIVSPAHTPN 2410 WDLVSDVVNS 2420 CSRIYRSSKQ 2430 CRNRYENVII 2440 PREEGKSKNN 2450 RPLRTSQIYA 2460 QDENATHTQL 2470 YTSHFDLMKM 2480 TAGKRSPPIK 2490 PLLGMNPFQK 2500 NPKHASVLAE 2510 SGINYDKPLP 2520 PIQVASLRAE 2530 RIAKEKKALA 2540 DQQKAQQPAV 2550 AQPPPPQPQP 2560 PPPPQQPPPP 2570 LPQPQAAGSQ 2580 PPAGPPAVQP 2590 QPQPQPQTQP 2600 QPVQAPAKAQ 2610 PAITTGGSAA 2620 VLAGTIKTSV 2630 TGTSMPTGAV 2640 SGNVIVNTIA 2650 GVPAATFQSI 2660 NKRLASPVAP 2670 GALTTPGGSA 2680 PAQVVHTQPP 2690 PRAVGSPATA 2700 TPDLVSMATT 2710 QGVRAVTSVT 2720 ASAVVTTNLT 2730 PVQTPARSLV 2740 PQVSQATGVQ 2750 LPGKTITPAH 2760 FQLLRQQQQQ 2770 QQQQQQQQQQ 2780 QQQQQQQQQQ 2790 QQQQTTTTSQ 2800 VQVPQIQGQA 2810 QSPAQIKAVG 2820 KLTPEHLIKM 2830 QKQKLQMPPQ 2840 PPPPQAQSAP 2850 PQPTAQVQVQ 2860 TSQPPQQQSP 2870 QLTTVTAPRP 2880 GALLTGTTVA 2890 NLQVARLTRV 2900 PTSQLQAQGQ 2910 MQTQAPQPAQ 2920 VALAKPPVVS 2930 VPAAVVSSPG 2940 VTTLPMNVAG 2950 ISVAIGQPQK 2960 AAGQTVVAQP 2970 VHMQQLLKLK 2980 QQAVQQQKAI 2990 QPQAAQGPAA 3000 VQQKITAQQI 3010 TTPGAQQKVA 3020 YAAQPALKTQ 3030 FLTTPISQAQ 3040 KLAGAQQVQT 3050 QIQVAKLPQV 3060 VQQQTPVASI 3070 QQVASASQQA 3080 SPQTVALTQA 3090 TAAGQQVQMI 3100 PAVTATAQVV 3110 QQKLIQQQVV 3120 TTASAPLQTP 3130 GAPNPAQVPA 3140 SSDSPSQQPK 3150 LQMRVPAVRL KTPTKPPCQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035267	NuA4 histone acetyltransferase complex
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0000812	Swr1 complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0004386	helicase activity
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:1990405	protein antigen binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:2000779	regulation of double-strand break repair

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.